Lateral medullary stroke in patient with granulomatous polyangiitis

Olha Taraschenko, Colum F. Amory, Jonathan Waldman, Era K. Hanspal, Gary L. Bernardini

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Granulomatous polyangiitis (GPA), also known as Wegener granulomatosis, is a systemic antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis that infrequently affects the central nervous system. We report a 41-year-old man with lateral medullary infarction who developed rapidly progressive renal failure. He was diagnosed with GPA based on positive serum c-ANCA and antiproteinase 3 antibodies and demonstration of pauci-immune crescentic glomerulonephritis on kidney biopsy. He was treated with Coumadin, pulse steroids, cyclophosphamide, and plasmapheresis. He had resolution of his neurologic deficits and improvement in renal function. This case report highlights the importance to consider GPA vasculitis in the differential diagnosis of stroke in patients with development of acute kidney injury.

Original languageEnglish (US)
Pages (from-to)1259-1261
Number of pages3
JournalJournal of Stroke and Cerebrovascular Diseases
Volume23
Issue number5
DOIs
StatePublished - Jan 1 2014

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Antineutrophil Cytoplasmic Antibodies
Vasculitis
Stroke
Kidney
Granulomatosis with Polyangiitis
Plasmapheresis
Warfarin
Glomerulonephritis
Neurologic Manifestations
Acute Kidney Injury
Cyclophosphamide
Infarction
Renal Insufficiency
Differential Diagnosis
Central Nervous System
Steroids
Biopsy
Antibodies
Serum
cytoplasmic antiproteinase

Keywords

  • Stroke
  • Wegener granulomatosis
  • granulomatous polyangiitis
  • kidney injury
  • medulla oblongata

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Rehabilitation
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Lateral medullary stroke in patient with granulomatous polyangiitis. / Taraschenko, Olha; Amory, Colum F.; Waldman, Jonathan; Hanspal, Era K.; Bernardini, Gary L.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 23, No. 5, 01.01.2014, p. 1259-1261.

Research output: Contribution to journalArticle

Taraschenko, Olha ; Amory, Colum F. ; Waldman, Jonathan ; Hanspal, Era K. ; Bernardini, Gary L. / Lateral medullary stroke in patient with granulomatous polyangiitis. In: Journal of Stroke and Cerebrovascular Diseases. 2014 ; Vol. 23, No. 5. pp. 1259-1261.
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