Lateral hypothalamic activity indicates hunger and satiety states in humans

Omid Talakoub, Raquel R. Paiva, Matija Milosevic, Marcelo Q. Hoexter, Ruth Franco, Eduardo Alho, Jessie Navarro, José F. Pereira, Milos R. Popovic, Cary Savage, Antonio C. Lopes, Pedro Alvarenga, Durval Damiani, Manoel J. Teixeira, Euripides C. Miguel, Erich T. Fonoff, Marcelo C. Batistuzzo, Clement Hamani

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Lateral hypothalamic area (LHA) local field potentials (LFPs) were recorded in a Prader–Willi patient undergoing deep brain stimulation (DBS) for obesity. During hunger, exposure to food-related cues induced an increase in beta/low-gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alpha-frequency DBS prior to and during food intake. Despite reporting an early sensation of fullness, the patient continued to crave food. This suggests that the pattern of activity in LHA may indicate hunger/satiety states in humans but attest to the complexity of conducting neuromodulation studies in obesity.

Original languageEnglish (US)
Pages (from-to)897-901
Number of pages5
JournalAnnals of Clinical and Translational Neurology
Volume4
Issue number12
DOIs
StatePublished - Dec 2017

Keywords

  • Obesity
  • Prader-Willi syndrome
  • deep brain stimulation
  • hunger
  • hypothalamus
  • satiety

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Talakoub, O., Paiva, R. R., Milosevic, M., Hoexter, M. Q., Franco, R., Alho, E., Navarro, J., Pereira, J. F., Popovic, M. R., Savage, C., Lopes, A. C., Alvarenga, P., Damiani, D., Teixeira, M. J., Miguel, E. C., Fonoff, E. T., Batistuzzo, M. C., & Hamani, C. (2017). Lateral hypothalamic activity indicates hunger and satiety states in humans. Annals of Clinical and Translational Neurology, 4(12), 897-901. https://doi.org/10.1002/acn3.466