Late-migrating neuroepithelial cells from the spinal cord differentiate into sensory ganglion cells and melanocytes

Kamal Sharma, Zeljka Korade, Eric Frank

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

During embryonic development, neural crest cells give rise to many structures in peripheral tissues. Other neural tube cells are thought to contribute only to structures within the CNS. In contrast to this idea, we report a second wave of migration of cells away from the spinal cord occurring after the emigration of crest cells is complete. Neuroepithelial cells from spinal cords in E5 chicken embryos migrate into the periphery and differentiate into neurons and satellite cells within sensory ganglia and into melanocytes in skin and feathers. These results show that some cell types previously considered to be the descendants exclusively of neural crest cells are also derived from neuroepithelial cells in the spinal cord.

Original languageEnglish (US)
Pages (from-to)143-152
Number of pages10
JournalNeuron
Volume14
Issue number1
DOIs
StatePublished - Jan 1995

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Neuroepithelial Cells
Sensory Ganglia
Melanocytes
Spinal Cord
Neural Crest
Feathers
Neural Tube
Emigration and Immigration
Embryonic Development
Cell Movement
Chickens
Embryonic Structures
Neurons
Skin

ASJC Scopus subject areas

  • Neuroscience(all)

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Late-migrating neuroepithelial cells from the spinal cord differentiate into sensory ganglion cells and melanocytes. / Sharma, Kamal; Korade, Zeljka; Frank, Eric.

In: Neuron, Vol. 14, No. 1, 01.1995, p. 143-152.

Research output: Contribution to journalArticle

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