Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children

J. A. Vanderhoof, D. B. Whitney, D. L. Antonson, T. L. Hanner, J. V. Lupo, R. J. Young

Research output: Contribution to journalArticle

421 Scopus citations


The objective of this study was to determine the efficacy of Lactobacillus casei sps. rhamnosus (Lactobacillus GG) (LGG) in reducing the incidence of antibiotic-associated diarrhea when coadministered with an oral antibiotic in children with acute infectious disorders. Study design: Two hundred two children between 6 months and 10 years of age were enrolled; 188 completed all phases of the protocol. LGG, 1 x 1010 - 2 x 1010 colony forming units per day, or comparable placebo was administered in a double- blind randomized trial to children receiving oral antibiotic therapy in an outpatient setting. The primary caregiver was questioned every 3 days regarding the incidence of gastrointestinal symptoms, predominantly stool frequency and consistency, through telephone contact by blinded investigators. Results: Twenty-five placebo-treated but only 7 LGG-treated patients had diarrhea as defined by liquid stools numbering 2 or greater per day. Lactobacillus GG overall significantly reduced stool frequency and increased stool consistency during antibiotic therapy by the tenth day compared with the placebo group. Conclusion: Lactobacillus GG reduces the incidence of antibiotic-associated diarrhea in children treated with oral antibiotics for common childhood infections.

Original languageEnglish (US)
Pages (from-to)564-568
Number of pages5
JournalJournal of Pediatrics
Issue number5
StatePublished - Jan 1 1999


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Vanderhoof, J. A., Whitney, D. B., Antonson, D. L., Hanner, T. L., Lupo, J. V., & Young, R. J. (1999). Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. Journal of Pediatrics, 135(5), 564-568.