9 Scopus citations

Abstract

Among mycobacteria, Mycobacterium leprae have a unique property to infect peripheral nerves, which is the cause of a variety of debilities seen in leprosy. The possibility of selective uptake of M. leprae by Schwann cells was studied using a rat Schwannoma cell line 33B and rat sciatic nerve-derived Schwann cells. M. leprae were phagocytosed by 33B cells but so also were seven other mycobacteria ('Mycobacterium w,' BCG, M. tuberculosis H37Rv, M. non-chromogenicum, M. vaccae, ICRC bacillus, and M. smegmatis) which do not involve peripheral nerves. All three mycobacteria tested (M. leprae, M. tuberculosis and 'Mycobacterium w') were phagocytosed by sciatic nerve-derived Schwann cells. Both Schwannoma and Schwann cells phagocytosed even inert latex particles. These results fail to demonstrate any M. leprae-specific uptake system in Schwann cells.

Original languageEnglish (US)
Pages (from-to)71-78
Number of pages8
JournalInternational Journal of Leprosy
Volume54
Issue number1
StatePublished - Jan 1 1986

    Fingerprint

ASJC Scopus subject areas

  • Dermatology

Cite this