Lack of correlation between serum levels of E- and P-cadherin fragments and the presence of breast cancer

Karen A. Knudsen, Chen Yan Lin, Keith R. Johnson, Margaret J. Wheelock, Albert A. Keshgegian, Alejandro Peralta Soler

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Breast cancers often show reduced expression of the transmembrane cell-cell adhesion protein, E-cadherin. In addition, approximately half of breast carcinomas express P-cadherin, which correlates with poor survival. A large fragment of the E-cadherin extracellular domain can be detected in serum, and it has been proposed that an increase in serum E-cadherin can denote the presence of a tumor. In this study, we tested the possibility that serum E- or P-cadherin levels might be useful diagnostic or prognostic indicators in breast cancer. However, we found no indication that the level of serum E-cadherin correlated with the presence of breast cancer. In addition, although we successfully detected a fragment of P-cadherin in serum, we found that its level was considerably lower than that of E-cadherin and did not correlate with the presence of P-cadherin-positive breast cancer. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)961-965
Number of pages5
JournalHuman Pathology
Volume31
Issue number8
DOIs
StatePublished - Jan 1 2000

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Keywords

  • Breast tissue
  • Cancer
  • E-cadherin
  • P-cadherin
  • Serum levels

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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