Lack of correlation between serum levels of E- and P-cadherin fragments and the presence of breast cancer

Karen A. Knudsen, Chen Yan Lin, Keith R Johnson, Margaret J. Wheelock, Albert A. Keshgegian, Alejandro Peralta Soler

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Breast cancers often show reduced expression of the transmembrane cell-cell adhesion protein, E-cadherin. In addition, approximately half of breast carcinomas express P-cadherin, which correlates with poor survival. A large fragment of the E-cadherin extracellular domain can be detected in serum, and it has been proposed that an increase in serum E-cadherin can denote the presence of a tumor. In this study, we tested the possibility that serum E- or P-cadherin levels might be useful diagnostic or prognostic indicators in breast cancer. However, we found no indication that the level of serum E-cadherin correlated with the presence of breast cancer. In addition, although we successfully detected a fragment of P-cadherin in serum, we found that its level was considerably lower than that of E-cadherin and did not correlate with the presence of P-cadherin-positive breast cancer. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)961-965
Number of pages5
JournalHuman Pathology
Volume31
Issue number8
DOIs
StatePublished - Jan 1 2000

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Cadherins
Breast Neoplasms
Serum
Cell Adhesion

Keywords

  • Breast tissue
  • Cancer
  • E-cadherin
  • P-cadherin
  • Serum levels

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Lack of correlation between serum levels of E- and P-cadherin fragments and the presence of breast cancer. / Knudsen, Karen A.; Lin, Chen Yan; Johnson, Keith R; Wheelock, Margaret J.; Keshgegian, Albert A.; Soler, Alejandro Peralta.

In: Human Pathology, Vol. 31, No. 8, 01.01.2000, p. 961-965.

Research output: Contribution to journalArticle

Knudsen, Karen A. ; Lin, Chen Yan ; Johnson, Keith R ; Wheelock, Margaret J. ; Keshgegian, Albert A. ; Soler, Alejandro Peralta. / Lack of correlation between serum levels of E- and P-cadherin fragments and the presence of breast cancer. In: Human Pathology. 2000 ; Vol. 31, No. 8. pp. 961-965.
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