Lack of clinical benefit after treatment of systemic sclerosis with total lymphoid irradiation

James Robert O'Dell, J. C. Steigerwald, R. C. Kennaugh, R. Hawkins, V. M. Holers, B. L. Kotzin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Six patients with systemic sclerosis and internal organ involvement were randomized to receive total lymphoid irradiation (TLI) or to serve as untreated controls. Despite evidence of profound immunosuppression, were unable to detect any longlasting clinical benefit in the treated patients, with followups ranging from 1-4 years after TLI. Moreover, the results suggest that this therapy may accelerate pulmonary and gastrointestinal deterioration in scleroderma.

Original languageEnglish (US)
Pages (from-to)1050-1054
Number of pages5
JournalJournal of Rheumatology
Volume16
Issue number8
StatePublished - Jan 1 1989

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Lymphatic Irradiation
Systemic Scleroderma
Immunosuppression
Lung
Therapeutics

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

O'Dell, J. R., Steigerwald, J. C., Kennaugh, R. C., Hawkins, R., Holers, V. M., & Kotzin, B. L. (1989). Lack of clinical benefit after treatment of systemic sclerosis with total lymphoid irradiation. Journal of Rheumatology, 16(8), 1050-1054.

Lack of clinical benefit after treatment of systemic sclerosis with total lymphoid irradiation. / O'Dell, James Robert; Steigerwald, J. C.; Kennaugh, R. C.; Hawkins, R.; Holers, V. M.; Kotzin, B. L.

In: Journal of Rheumatology, Vol. 16, No. 8, 01.01.1989, p. 1050-1054.

Research output: Contribution to journalArticle

O'Dell, JR, Steigerwald, JC, Kennaugh, RC, Hawkins, R, Holers, VM & Kotzin, BL 1989, 'Lack of clinical benefit after treatment of systemic sclerosis with total lymphoid irradiation', Journal of Rheumatology, vol. 16, no. 8, pp. 1050-1054.
O'Dell JR, Steigerwald JC, Kennaugh RC, Hawkins R, Holers VM, Kotzin BL. Lack of clinical benefit after treatment of systemic sclerosis with total lymphoid irradiation. Journal of Rheumatology. 1989 Jan 1;16(8):1050-1054.
O'Dell, James Robert ; Steigerwald, J. C. ; Kennaugh, R. C. ; Hawkins, R. ; Holers, V. M. ; Kotzin, B. L. / Lack of clinical benefit after treatment of systemic sclerosis with total lymphoid irradiation. In: Journal of Rheumatology. 1989 ; Vol. 16, No. 8. pp. 1050-1054.
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