L-asparaginase-induced hypocomplementemia in acute lymphocytic leukemia (ALL) of childhood

Ralph Shapiro, Youngki Kim, Alfred F. Michael, Jonathan M. Gerrard, Mark Nesbit, Peter Felix Coccia, Norma K.C. Ramsay, William Krivit

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Serum complement studies were carried out in five children with acute lymphocytic leukemia. During therapy with L-asparaginase, prednisone and vincristine, hypocomplementemia developed in all patients, and disappeared within 2 weeks after the discontinuation of L-asparaginase. Complement breakdown products were not present in plasma. The changes of serum complement levels paralleled those of plasma fibrinogen. These findings suggest that the hypocomplementemia observed in these patients may be related to impaired protein synthesis induced by L-asparaginase.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume1
Issue number1
StatePublished - Jan 1 1979

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Asparaginase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Vincristine
Prednisone
Serum
Fibrinogen
Proteins
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Shapiro, R., Kim, Y., Michael, A. F., Gerrard, J. M., Nesbit, M., Coccia, P. F., ... Krivit, W. (1979). L-asparaginase-induced hypocomplementemia in acute lymphocytic leukemia (ALL) of childhood. American Journal of Pediatric Hematology/Oncology, 1(1), 5-7.

L-asparaginase-induced hypocomplementemia in acute lymphocytic leukemia (ALL) of childhood. / Shapiro, Ralph; Kim, Youngki; Michael, Alfred F.; Gerrard, Jonathan M.; Nesbit, Mark; Coccia, Peter Felix; Ramsay, Norma K.C.; Krivit, William.

In: American Journal of Pediatric Hematology/Oncology, Vol. 1, No. 1, 01.01.1979, p. 5-7.

Research output: Contribution to journalArticle

Shapiro, R, Kim, Y, Michael, AF, Gerrard, JM, Nesbit, M, Coccia, PF, Ramsay, NKC & Krivit, W 1979, 'L-asparaginase-induced hypocomplementemia in acute lymphocytic leukemia (ALL) of childhood', American Journal of Pediatric Hematology/Oncology, vol. 1, no. 1, pp. 5-7.
Shapiro R, Kim Y, Michael AF, Gerrard JM, Nesbit M, Coccia PF et al. L-asparaginase-induced hypocomplementemia in acute lymphocytic leukemia (ALL) of childhood. American Journal of Pediatric Hematology/Oncology. 1979 Jan 1;1(1):5-7.
Shapiro, Ralph ; Kim, Youngki ; Michael, Alfred F. ; Gerrard, Jonathan M. ; Nesbit, Mark ; Coccia, Peter Felix ; Ramsay, Norma K.C. ; Krivit, William. / L-asparaginase-induced hypocomplementemia in acute lymphocytic leukemia (ALL) of childhood. In: American Journal of Pediatric Hematology/Oncology. 1979 ; Vol. 1, No. 1. pp. 5-7.
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