KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin

T. A. Wyatt, K. B. Pryzwansky, T. M. Lincoln

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Abstract

The effectiveness of the cGMP-dependent protein kinase inhibitor, KT5823, was investigated in human neutrophils. KT5823 did not inhibit the cGMP-dependent protein kinase mediated in vitro, or in situ phosphorylation of vimentin, a known substrate for this enzyme in activated neutrophils. In addition, KT5823 was shown to induce dramatic shape changes in neutrophils, suggesting it has an activating effect upon the cells.

Original languageEnglish (US)
Pages (from-to)3-14
Number of pages12
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume74
Issue number1
StatePublished - Nov 7 1991

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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