Kinetics of synaptic transmission at ribbon synapses of rods and cones

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

The ribbon synapse is a specialized structure that allows photoreceptors to sustain the continuous release of vesicles for hours upon hours and years upon years but also respond rapidly to momentary changes in illumination. Light responses of cones are faster than those of rods and, mirroring this difference, synaptic transmission from cones is also faster than transmission from rods. This review evaluates the various factors that regulate synaptic kinetics and contribute to kinetic differences between rod and cone synapses. Presynaptically, the release of glutamate-laden synaptic vesicles is regulated by properties of the synaptic proteins involved in exocytosis, influx of calcium through calcium channels, calcium release from intracellular stores, diffusion of calcium to the release site, calcium buffering, and extrusion of calcium from the cytoplasm. The rate of vesicle replenishment also limits the ability of the synapse to follow changes in release. Post-synaptic factors include properties of glutamate receptors, dynamics of glutamate diffusion through the cleft, and glutamate uptake by glutamate transporters. Thus, multiple synaptic mechanisms help to shape the responses of second-order horizontal and bipolar cells.

Original languageEnglish (US)
Pages (from-to)205-223
Number of pages19
JournalMolecular Neurobiology
Volume36
Issue number3
DOIs
StatePublished - Jan 1 2007

Fingerprint

Vertebrate Photoreceptor Cells
Synaptic Transmission
Synapses
Calcium
Glutamic Acid
Amino Acid Transport System X-AG
Synaptic Vesicles
Exocytosis
Glutamate Receptors
Calcium Channels
Lighting
Cytoplasm
Light
Proteins

Keywords

  • Calcium
  • Glutamate
  • Photoreceptor
  • Retina
  • Synaptic transmission
  • Vesicles

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Kinetics of synaptic transmission at ribbon synapses of rods and cones. / Thoreson, Wallace B.

In: Molecular Neurobiology, Vol. 36, No. 3, 01.01.2007, p. 205-223.

Research output: Contribution to journalReview article

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