Kidney cancer

Robert J. Motzer, Neeraj Agarwal, Clair Beard, Graeme B. Bolger, Barry Boston, Michael A. Carducci, Toni K. Choueiri, Robert A. Figlin, Mayer Fishman, Steven L. Hancock, Gary R. Hudes, Eric Jonasch, Margaret Anne Kessinger, Timothy M. Kuzel, Paul H. Lange, Ellis G. Levine, Kim A. Margolin, M. Dror Michaelson, Thomas Olencki, Roberto Pili & 5 others Bruce G. Redman, Cary N. Robertson, Lawrence H. Schwartz, Joel Sheinfeld, Jue Wang

Research output: Contribution to journalReview article

144 Citations (Scopus)

Abstract

In 2008, an estimated 54,390 Americans were diagnosed with and 13,010 died of kidney cancer in the United States. The rate of renal cell carcinoma (RCC) has increased 2% per year for the past 65 years. Smoking and obesity are among the risk factors for RCC development, with tumor grade, local extent of the tumor, presence of regional nodal metastases, and evidence of metastatic disease at presentation the most important prognostic determinants of 5-year survival. These guidelines discuss evaluation, staging, treatment, and management after treatment. Important updates for 2009 include the addition of everolimus as second-line therapy after a tyrosine kinase inhibitor and the change to a category 1 recommendation for bevaciumab and interferon for first-line therapy for clear cell histologies.

Original languageEnglish (US)
Pages (from-to)618-630
Number of pages13
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume7
Issue number6
DOIs
StatePublished - Jan 1 2009

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Kidney Neoplasms
Renal Cell Carcinoma
Cell- and Tissue-Based Therapy
Protein-Tyrosine Kinases
Interferons
Neoplasms
Histology
Therapeutics
Obesity
Smoking
Guidelines
Neoplasm Metastasis

Keywords

  • Clear cell tumors
  • Kidney disease
  • NCCN Clinical Practice Guidelines
  • Nephrectomy
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Oncology

Cite this

Motzer, R. J., Agarwal, N., Beard, C., Bolger, G. B., Boston, B., Carducci, M. A., ... Wang, J. (2009). Kidney cancer. JNCCN Journal of the National Comprehensive Cancer Network, 7(6), 618-630. https://doi.org/10.6004/jnccn.2009.0043

Kidney cancer. / Motzer, Robert J.; Agarwal, Neeraj; Beard, Clair; Bolger, Graeme B.; Boston, Barry; Carducci, Michael A.; Choueiri, Toni K.; Figlin, Robert A.; Fishman, Mayer; Hancock, Steven L.; Hudes, Gary R.; Jonasch, Eric; Kessinger, Margaret Anne; Kuzel, Timothy M.; Lange, Paul H.; Levine, Ellis G.; Margolin, Kim A.; Michaelson, M. Dror; Olencki, Thomas; Pili, Roberto; Redman, Bruce G.; Robertson, Cary N.; Schwartz, Lawrence H.; Sheinfeld, Joel; Wang, Jue.

In: JNCCN Journal of the National Comprehensive Cancer Network, Vol. 7, No. 6, 01.01.2009, p. 618-630.

Research output: Contribution to journalReview article

Motzer, RJ, Agarwal, N, Beard, C, Bolger, GB, Boston, B, Carducci, MA, Choueiri, TK, Figlin, RA, Fishman, M, Hancock, SL, Hudes, GR, Jonasch, E, Kessinger, MA, Kuzel, TM, Lange, PH, Levine, EG, Margolin, KA, Michaelson, MD, Olencki, T, Pili, R, Redman, BG, Robertson, CN, Schwartz, LH, Sheinfeld, J & Wang, J 2009, 'Kidney cancer', JNCCN Journal of the National Comprehensive Cancer Network, vol. 7, no. 6, pp. 618-630. https://doi.org/10.6004/jnccn.2009.0043
Motzer RJ, Agarwal N, Beard C, Bolger GB, Boston B, Carducci MA et al. Kidney cancer. JNCCN Journal of the National Comprehensive Cancer Network. 2009 Jan 1;7(6):618-630. https://doi.org/10.6004/jnccn.2009.0043
Motzer, Robert J. ; Agarwal, Neeraj ; Beard, Clair ; Bolger, Graeme B. ; Boston, Barry ; Carducci, Michael A. ; Choueiri, Toni K. ; Figlin, Robert A. ; Fishman, Mayer ; Hancock, Steven L. ; Hudes, Gary R. ; Jonasch, Eric ; Kessinger, Margaret Anne ; Kuzel, Timothy M. ; Lange, Paul H. ; Levine, Ellis G. ; Margolin, Kim A. ; Michaelson, M. Dror ; Olencki, Thomas ; Pili, Roberto ; Redman, Bruce G. ; Robertson, Cary N. ; Schwartz, Lawrence H. ; Sheinfeld, Joel ; Wang, Jue. / Kidney cancer. In: JNCCN Journal of the National Comprehensive Cancer Network. 2009 ; Vol. 7, No. 6. pp. 618-630.
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