Ketamine-induced gastroprotection during endotoxemia: Role of heme-oxygenase-1

Kenneth S. Helmer, James W. Suliburk, David W. Mercer

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Inducible nitric oxide synthase contributes to lipopolysacharide-induced gastric injury. In contrast, heme-oxygenase-1 has anti-inflammatory effects and is protective against oxidative tissue injury. Ketamine attenuates injury from lipopolysacharide and is associated with changes in oxidative stress proteins, but its effects on the stomach remain to be fully elucidated. We hypothesized that ketamine would diminish gastric injury from lipopolysacharide via down-regulation of nuclear factor-κß, activator protein-1, and inducible nitric oxide synthase, as well as up-regulation of heme-oxygenase-1. Ketamine up-regulated heme-oxygenase-1 and attenuated lipopolysacharide-induced changes in gastric nuclear factor-κß, activator protein-1, and inducible nitric oxide synthase. Ketamine negated LPS-induced gastric injury from acidified ethanol, an effect reversed by tin protoporphorin IX. Ketamine diminishes the susceptibility of gastric mucosa to damage from luminal irritants during endotoxemia, which is mediated in part by down-regulation of iNOS and up-regulation of HO-1.

Original languageEnglish (US)
Pages (from-to)1571-1581
Number of pages11
JournalDigestive Diseases and Sciences
Volume51
Issue number9
DOIs
StatePublished - Sep 1 2006

Fingerprint

Heme Oxygenase-1
Endotoxemia
Ketamine
Stomach
Nitric Oxide Synthase Type II
Wounds and Injuries
Transcription Factor AP-1
Up-Regulation
Down-Regulation
Tin
Irritants
Heat-Shock Proteins
Gastric Mucosa
Oxidative Stress
Anti-Inflammatory Agents
Ethanol

Keywords

  • AP-1
  • Gastric injury
  • HO-1
  • Heme-oxygenase
  • Lipopolysacharide
  • Mild irritants
  • NF-κß
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Ketamine-induced gastroprotection during endotoxemia : Role of heme-oxygenase-1. / Helmer, Kenneth S.; Suliburk, James W.; Mercer, David W.

In: Digestive Diseases and Sciences, Vol. 51, No. 9, 01.09.2006, p. 1571-1581.

Research output: Contribution to journalArticle

Helmer, Kenneth S. ; Suliburk, James W. ; Mercer, David W. / Ketamine-induced gastroprotection during endotoxemia : Role of heme-oxygenase-1. In: Digestive Diseases and Sciences. 2006 ; Vol. 51, No. 9. pp. 1571-1581.
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