Kaposi's sarcoma-associated herpesvirus seropositivity is associated with type 2 diabetes mellitus: A case–control study in Xinjiang, China

Meng Cui, Qiwen Fang, Jun Zheng, Zhanjun Shu, Yin Chen, Yage Fan, Juan Zhao, Charles Wood, Tiejun Zhang, Yan Zeng

Research output: Contribution to journalArticle

Abstract

Objective: To assess the potential relationship between Kaposi's sarcoma-associated herpesvirus (KSHV) infection and type 2 diabetes mellitus (DM-2) in Xinjiang, China. Methods: A case–control study of consecutively included DM-2 patients and normal controls was conducted among the Uygur and Han populations in Xinjiang Uygur Autonomous Region, China. Blood samples were collected and KSHV seroprevalence, antibody titers, and viral load were investigated. Logistic regression analysis and multiple linear regression analysis were applied to explore determinants of the main outcome measures. Results: A total of 324 patients with DM-2 and 376 normal controls were included. The seroprevalence of KSHV was 49.1% (95% confidence interval (CI) 43.6–54.5%) for diabetic patients and 23.7% (95% CI 19.4–28.0%) for the control group. After adjusting for variables of ethnicity, sex, body mass index, occupation, educational level, marital status, age, and smoking and alcohol consumption habits, the association between DM-2 and KSHV infection still existed (odds ratio (OR) 2.94, 95% CI 2.05–4.22), and the risk of KSHV infection increased with glucose concentration (OR 1.35, 95% CI 1.21–1.51). KSHV was more likely to express both the latent and lytic antigens in diabetic patients (latent: OR 3.27, 95% CI 2.25–4.75; lytic: OR 3.99, 95% CI 2.68–5.93). Antibody titers and viral load increased in patients with higher blood glucose levels (p < 0.001). Conclusions: Patients with DM-2 have an elevated risk of KSHV infection. Both antibody titers and viral load increased with blood glucose levels.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalInternational Journal of Infectious Diseases
Volume80
DOIs
StatePublished - Mar 2019

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Human Herpesvirus 8
Type 2 Diabetes Mellitus
China
Herpesviridae Infections
Confidence Intervals
Viral Load
Odds Ratio
Seroepidemiologic Studies
Blood Glucose
Antibodies
Regression Analysis
Marital Status
Occupations
Alcohol Drinking
Habits
Linear Models
Body Mass Index
Logistic Models
Smoking
Outcome Assessment (Health Care)

Keywords

  • Antibodies
  • Diabetes mellitus, type 2
  • Herpesvirus 8, human
  • Seroepidemiological studies
  • Viral load

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Kaposi's sarcoma-associated herpesvirus seropositivity is associated with type 2 diabetes mellitus : A case–control study in Xinjiang, China. / Cui, Meng; Fang, Qiwen; Zheng, Jun; Shu, Zhanjun; Chen, Yin; Fan, Yage; Zhao, Juan; Wood, Charles; Zhang, Tiejun; Zeng, Yan.

In: International Journal of Infectious Diseases, Vol. 80, 03.2019, p. 73-79.

Research output: Contribution to journalArticle

Cui, Meng ; Fang, Qiwen ; Zheng, Jun ; Shu, Zhanjun ; Chen, Yin ; Fan, Yage ; Zhao, Juan ; Wood, Charles ; Zhang, Tiejun ; Zeng, Yan. / Kaposi's sarcoma-associated herpesvirus seropositivity is associated with type 2 diabetes mellitus : A case–control study in Xinjiang, China. In: International Journal of Infectious Diseases. 2019 ; Vol. 80. pp. 73-79.
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abstract = "Objective: To assess the potential relationship between Kaposi's sarcoma-associated herpesvirus (KSHV) infection and type 2 diabetes mellitus (DM-2) in Xinjiang, China. Methods: A case–control study of consecutively included DM-2 patients and normal controls was conducted among the Uygur and Han populations in Xinjiang Uygur Autonomous Region, China. Blood samples were collected and KSHV seroprevalence, antibody titers, and viral load were investigated. Logistic regression analysis and multiple linear regression analysis were applied to explore determinants of the main outcome measures. Results: A total of 324 patients with DM-2 and 376 normal controls were included. The seroprevalence of KSHV was 49.1{\%} (95{\%} confidence interval (CI) 43.6–54.5{\%}) for diabetic patients and 23.7{\%} (95{\%} CI 19.4–28.0{\%}) for the control group. After adjusting for variables of ethnicity, sex, body mass index, occupation, educational level, marital status, age, and smoking and alcohol consumption habits, the association between DM-2 and KSHV infection still existed (odds ratio (OR) 2.94, 95{\%} CI 2.05–4.22), and the risk of KSHV infection increased with glucose concentration (OR 1.35, 95{\%} CI 1.21–1.51). KSHV was more likely to express both the latent and lytic antigens in diabetic patients (latent: OR 3.27, 95{\%} CI 2.25–4.75; lytic: OR 3.99, 95{\%} CI 2.68–5.93). Antibody titers and viral load increased in patients with higher blood glucose levels (p < 0.001). Conclusions: Patients with DM-2 have an elevated risk of KSHV infection. Both antibody titers and viral load increased with blood glucose levels.",
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T1 - Kaposi's sarcoma-associated herpesvirus seropositivity is associated with type 2 diabetes mellitus

T2 - A case–control study in Xinjiang, China

AU - Cui, Meng

AU - Fang, Qiwen

AU - Zheng, Jun

AU - Shu, Zhanjun

AU - Chen, Yin

AU - Fan, Yage

AU - Zhao, Juan

AU - Wood, Charles

AU - Zhang, Tiejun

AU - Zeng, Yan

PY - 2019/3

Y1 - 2019/3

N2 - Objective: To assess the potential relationship between Kaposi's sarcoma-associated herpesvirus (KSHV) infection and type 2 diabetes mellitus (DM-2) in Xinjiang, China. Methods: A case–control study of consecutively included DM-2 patients and normal controls was conducted among the Uygur and Han populations in Xinjiang Uygur Autonomous Region, China. Blood samples were collected and KSHV seroprevalence, antibody titers, and viral load were investigated. Logistic regression analysis and multiple linear regression analysis were applied to explore determinants of the main outcome measures. Results: A total of 324 patients with DM-2 and 376 normal controls were included. The seroprevalence of KSHV was 49.1% (95% confidence interval (CI) 43.6–54.5%) for diabetic patients and 23.7% (95% CI 19.4–28.0%) for the control group. After adjusting for variables of ethnicity, sex, body mass index, occupation, educational level, marital status, age, and smoking and alcohol consumption habits, the association between DM-2 and KSHV infection still existed (odds ratio (OR) 2.94, 95% CI 2.05–4.22), and the risk of KSHV infection increased with glucose concentration (OR 1.35, 95% CI 1.21–1.51). KSHV was more likely to express both the latent and lytic antigens in diabetic patients (latent: OR 3.27, 95% CI 2.25–4.75; lytic: OR 3.99, 95% CI 2.68–5.93). Antibody titers and viral load increased in patients with higher blood glucose levels (p < 0.001). Conclusions: Patients with DM-2 have an elevated risk of KSHV infection. Both antibody titers and viral load increased with blood glucose levels.

AB - Objective: To assess the potential relationship between Kaposi's sarcoma-associated herpesvirus (KSHV) infection and type 2 diabetes mellitus (DM-2) in Xinjiang, China. Methods: A case–control study of consecutively included DM-2 patients and normal controls was conducted among the Uygur and Han populations in Xinjiang Uygur Autonomous Region, China. Blood samples were collected and KSHV seroprevalence, antibody titers, and viral load were investigated. Logistic regression analysis and multiple linear regression analysis were applied to explore determinants of the main outcome measures. Results: A total of 324 patients with DM-2 and 376 normal controls were included. The seroprevalence of KSHV was 49.1% (95% confidence interval (CI) 43.6–54.5%) for diabetic patients and 23.7% (95% CI 19.4–28.0%) for the control group. After adjusting for variables of ethnicity, sex, body mass index, occupation, educational level, marital status, age, and smoking and alcohol consumption habits, the association between DM-2 and KSHV infection still existed (odds ratio (OR) 2.94, 95% CI 2.05–4.22), and the risk of KSHV infection increased with glucose concentration (OR 1.35, 95% CI 1.21–1.51). KSHV was more likely to express both the latent and lytic antigens in diabetic patients (latent: OR 3.27, 95% CI 2.25–4.75; lytic: OR 3.99, 95% CI 2.68–5.93). Antibody titers and viral load increased in patients with higher blood glucose levels (p < 0.001). Conclusions: Patients with DM-2 have an elevated risk of KSHV infection. Both antibody titers and viral load increased with blood glucose levels.

KW - Antibodies

KW - Diabetes mellitus, type 2

KW - Herpesvirus 8, human

KW - Seroepidemiological studies

KW - Viral load

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