Johne's disease, inflammatory bowel disease, and Mycobacterium paratuberculosis

Ofelia Chacon, Luiz E. Bermudez, Raul G Barletta

Research output: Contribution to journalReview article

191 Citations (Scopus)

Abstract

Johne's disease is a chronic diarrhea affecting all ruminants. Mycobacterium avium subsp. paratuberculosis (MAP), a slowly growing mycobacteria, is the etiologic agent. There is also a concern that MAP might be a causative agent of some cases of inflammatory bowel disease in humans, especially Crohn's disease. Food products including pasteurized bovine milk have been suggested as potential sources of human infection. This review addresses microbial factors that may contribute to its pathogenicity. In addition, the experimental evidence defining MAP as the cause of Johne's disease and the issues and controversies surrounding its potential pathogenic role in humans are discussed.

Original languageEnglish (US)
Pages (from-to)329-363
Number of pages35
JournalAnnual Review of Microbiology
Volume58
DOIs
StatePublished - Dec 7 2004

Fingerprint

Mycobacterium avium subsp. paratuberculosis
Paratuberculosis
Inflammatory Bowel Diseases
Mycobacterium avium
Ruminants
Mycobacterium
Crohn Disease
Virulence
Diarrhea
Milk
Food
Infection

Keywords

  • Crohn's disease
  • Diarrhea
  • Granulomatous enteritis
  • Mycobacteria
  • Ruminants

ASJC Scopus subject areas

  • Microbiology

Cite this

Johne's disease, inflammatory bowel disease, and Mycobacterium paratuberculosis. / Chacon, Ofelia; Bermudez, Luiz E.; Barletta, Raul G.

In: Annual Review of Microbiology, Vol. 58, 07.12.2004, p. 329-363.

Research output: Contribution to journalReview article

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