Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression

Kay Uwe Wagner, Hallgeir Rui

Research output: Contribution to journalReview article

105 Citations (Scopus)

Abstract

During normal mammary gland development, the tyrosine kinase Jak2 and its main substrate, the signal transducer and activator of transcription-5 (Stat5), are critical for the growth and differentiation of alveolar progenitors as well as the survival of secretory mammary epithelial cells. Genetic studies in mouse models support a role for the Stat5 transcription factor as a proto-oncogene in mammary tumor initiation. On the other hand, the analysis of nuclear Stat5 in human breast malignancies suggests a role of the Jak2/Stat5 pathway in the restriction of the metastatic potential of neoplastic mammary epithelial cells. Following an overview on the function of the Jak2/Stat5 pathway during normal mammary gland development, this review discusses recently published observations on human breast cancers as well as experimental evidence from genetically engineered mice that propose a dual role of Jak2/Stat5 signaling in breast cancer initiation and progression. Future studies to further test the concept of contrasting effects of Jak2/Stat5 pathway on breast cancer initiation and metastatic progression are proposed.

Original languageEnglish (US)
Pages (from-to)93-103
Number of pages11
JournalJournal of mammary gland biology and neoplasia
Volume13
Issue number1
DOIs
StatePublished - Mar 1 2008

Fingerprint

STAT5 Transcription Factor
Breast Neoplasms
Breast
Human Mammary Glands
Epithelial Cells
Proto-Oncogenes
Protein-Tyrosine Kinases
Transcription Factors
Growth

Keywords

  • Breast cancer initiation
  • Breast cancer progression
  • Jak2
  • Mammary gland development
  • Prolactin
  • Stat5

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression. / Wagner, Kay Uwe; Rui, Hallgeir.

In: Journal of mammary gland biology and neoplasia, Vol. 13, No. 1, 01.03.2008, p. 93-103.

Research output: Contribution to journalReview article

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abstract = "During normal mammary gland development, the tyrosine kinase Jak2 and its main substrate, the signal transducer and activator of transcription-5 (Stat5), are critical for the growth and differentiation of alveolar progenitors as well as the survival of secretory mammary epithelial cells. Genetic studies in mouse models support a role for the Stat5 transcription factor as a proto-oncogene in mammary tumor initiation. On the other hand, the analysis of nuclear Stat5 in human breast malignancies suggests a role of the Jak2/Stat5 pathway in the restriction of the metastatic potential of neoplastic mammary epithelial cells. Following an overview on the function of the Jak2/Stat5 pathway during normal mammary gland development, this review discusses recently published observations on human breast cancers as well as experimental evidence from genetically engineered mice that propose a dual role of Jak2/Stat5 signaling in breast cancer initiation and progression. Future studies to further test the concept of contrasting effects of Jak2/Stat5 pathway on breast cancer initiation and metastatic progression are proposed.",
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