Isolation and structure of the human cancer cell growth inhibitory phakellistatin 4 from the western Pacific sponge Phakellia costata

George R. Pettit, Jun ping Xu, Zbigniew Cichacz, Jean M. Schmidt, Ann Christine Dorsaz, Michael R. Boyd, Ronald Cerny

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Structural elucidation by high field 2D nmr and FAB-ms/ms techniques led to cyclo-(Pro-Thr-Pro-Phe-Ile-Phe-Ser) as the assignment for phakellistatin(4) a new cell growth inhibitory peptide from the Chuuk Archipelago marine sponge Phakellia costata.

Original languageEnglish (US)
Pages (from-to)501-506
Number of pages6
JournalHeterocycles
Volume40
Issue number2
Publication statusPublished - Mar 1 1995

    Fingerprint

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Cite this

Pettit, G. R., Xu, J. P., Cichacz, Z., Schmidt, J. M., Dorsaz, A. C., Boyd, M. R., & Cerny, R. (1995). Isolation and structure of the human cancer cell growth inhibitory phakellistatin 4 from the western Pacific sponge Phakellia costata. Heterocycles, 40(2), 501-506.