Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15

George R. Pettit, Yoshiaki Kamano, Claude Dufresne, Ronald Cerny, Cherry L. Herald, Jean M. Schmidt

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

The Indian Ocean sea hare Dolabella auricularia has been found to contain a strongly cytostatic depsipeptide constituent designated dolastatin 15. The unusual depsipeptide was found to markedly inhibit growth of the P388 lymphocytic leukemia cell line with ED50= 0.0024 μg/mL. The structure was elucidated by employing primarily high-field (400-MHz) 2D NMR and high-resolution mass spectrometry.

Original languageEnglish (US)
Pages (from-to)6005-6006
Number of pages2
JournalJournal of Organic Chemistry
Volume54
Issue number26
DOIs
StatePublished - Dec 1 1989

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Depsipeptides
Cytostatic Agents
Mass spectrometry
Cells
Nuclear magnetic resonance
dolastatin 15

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Pettit, G. R., Kamano, Y., Dufresne, C., Cerny, R., Herald, C. L., & Schmidt, J. M. (1989). Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15. Journal of Organic Chemistry, 54(26), 6005-6006. https://doi.org/10.1021/jo00287a003

Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15. / Pettit, George R.; Kamano, Yoshiaki; Dufresne, Claude; Cerny, Ronald; Herald, Cherry L.; Schmidt, Jean M.

In: Journal of Organic Chemistry, Vol. 54, No. 26, 01.12.1989, p. 6005-6006.

Research output: Contribution to journalArticle

Pettit, GR, Kamano, Y, Dufresne, C, Cerny, R, Herald, CL & Schmidt, JM 1989, 'Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15', Journal of Organic Chemistry, vol. 54, no. 26, pp. 6005-6006. https://doi.org/10.1021/jo00287a003
Pettit, George R. ; Kamano, Yoshiaki ; Dufresne, Claude ; Cerny, Ronald ; Herald, Cherry L. ; Schmidt, Jean M. / Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15. In: Journal of Organic Chemistry. 1989 ; Vol. 54, No. 26. pp. 6005-6006.
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