Isolation and structure of dolastatin 17

George R. Pettit, Jun Ping Xu, Fiona Hogan, Ronald Cerny

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The unusual cyclodepsipeptide dolastatin 17 (1) was isolated from the Papua New Guinea sea hare Dolabella auricularia and found to contain a new acetylenic β-amino acid designated dolayne (Doy). Dolastatin 17 exhibited significant human cancer cell growth inhibitory activity (GI50 0.45-0.74 μg/mL range).

Original languageEnglish (US)
Pages (from-to)491-496
Number of pages6
JournalHeterocycles
Volume47
Issue number1
StatePublished - Dec 1 1998

Fingerprint

Depsipeptides
Hares
Papua New Guinea
Cell growth
Oceans and Seas
Amino Acids
Growth
Neoplasms
dolastatin 1
2-hexadecynoic acid

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Cite this

Pettit, G. R., Xu, J. P., Hogan, F., & Cerny, R. (1998). Isolation and structure of dolastatin 17. Heterocycles, 47(1), 491-496.

Isolation and structure of dolastatin 17. / Pettit, George R.; Xu, Jun Ping; Hogan, Fiona; Cerny, Ronald.

In: Heterocycles, Vol. 47, No. 1, 01.12.1998, p. 491-496.

Research output: Contribution to journalArticle

Pettit, GR, Xu, JP, Hogan, F & Cerny, R 1998, 'Isolation and structure of dolastatin 17', Heterocycles, vol. 47, no. 1, pp. 491-496.
Pettit GR, Xu JP, Hogan F, Cerny R. Isolation and structure of dolastatin 17. Heterocycles. 1998 Dec 1;47(1):491-496.
Pettit, George R. ; Xu, Jun Ping ; Hogan, Fiona ; Cerny, Ronald. / Isolation and structure of dolastatin 17. In: Heterocycles. 1998 ; Vol. 47, No. 1. pp. 491-496.
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