Isolation and structure of axinastatin 5 from a republic of comoros marine sponge

George R. Pettit, Feng Gao, Jean M. Schmidt, Jean Charles Chapuis, Ronald Cerny

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The new cancer cell growth (human and murine) inhibitory (GI50 0.3 to 3.3 μg/ml) cyclo-octapeptide axinastatin 5 (2) was isolated in 3.8 x 10-7% yield from the Western Indian Ocean marine sponge Axinella cf. carteri. Structural elucidation was achieved by high field (400 and 500 MHz) 2 D-NMR techniques and the amino acid sequence was confirmed by results of NMR and high resolution mass spectral MS/MS interpretations. Other peptide cancer cell growth inhibitory constituents of this orange sponge were found to be the cyclic hepta- and octapeptides axinastatin 1 and hymenistatin 1 (1).

Original languageEnglish (US)
Pages (from-to)2935-2940
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number24
DOIs
StatePublished - Dec 22 1994

Fingerprint

Comoros
Cell growth
Porifera
Axinella
Nuclear magnetic resonance
Indian Ocean
Growth
Amino Acid Sequence
Neoplasms
Amino Acids
Peptides
axinastatin 5

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Isolation and structure of axinastatin 5 from a republic of comoros marine sponge. / Pettit, George R.; Gao, Feng; Schmidt, Jean M.; Chapuis, Jean Charles; Cerny, Ronald.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 24, 22.12.1994, p. 2935-2940.

Research output: Contribution to journalArticle

Pettit, George R. ; Gao, Feng ; Schmidt, Jean M. ; Chapuis, Jean Charles ; Cerny, Ronald. / Isolation and structure of axinastatin 5 from a republic of comoros marine sponge. In: Bioorganic and Medicinal Chemistry Letters. 1994 ; Vol. 4, No. 24. pp. 2935-2940.
@article{52ea59913a7443399914eff2bafc403d,
title = "Isolation and structure of axinastatin 5 from a republic of comoros marine sponge",
abstract = "The new cancer cell growth (human and murine) inhibitory (GI50 0.3 to 3.3 μg/ml) cyclo-octapeptide axinastatin 5 (2) was isolated in 3.8 x 10-7{\%} yield from the Western Indian Ocean marine sponge Axinella cf. carteri. Structural elucidation was achieved by high field (400 and 500 MHz) 2 D-NMR techniques and the amino acid sequence was confirmed by results of NMR and high resolution mass spectral MS/MS interpretations. Other peptide cancer cell growth inhibitory constituents of this orange sponge were found to be the cyclic hepta- and octapeptides axinastatin 1 and hymenistatin 1 (1).",
author = "Pettit, {George R.} and Feng Gao and Schmidt, {Jean M.} and Chapuis, {Jean Charles} and Ronald Cerny",
year = "1994",
month = "12",
day = "22",
doi = "10.1016/S0960-894X(01)80843-X",
language = "English (US)",
volume = "4",
pages = "2935--2940",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "24",

}

TY - JOUR

T1 - Isolation and structure of axinastatin 5 from a republic of comoros marine sponge

AU - Pettit, George R.

AU - Gao, Feng

AU - Schmidt, Jean M.

AU - Chapuis, Jean Charles

AU - Cerny, Ronald

PY - 1994/12/22

Y1 - 1994/12/22

N2 - The new cancer cell growth (human and murine) inhibitory (GI50 0.3 to 3.3 μg/ml) cyclo-octapeptide axinastatin 5 (2) was isolated in 3.8 x 10-7% yield from the Western Indian Ocean marine sponge Axinella cf. carteri. Structural elucidation was achieved by high field (400 and 500 MHz) 2 D-NMR techniques and the amino acid sequence was confirmed by results of NMR and high resolution mass spectral MS/MS interpretations. Other peptide cancer cell growth inhibitory constituents of this orange sponge were found to be the cyclic hepta- and octapeptides axinastatin 1 and hymenistatin 1 (1).

AB - The new cancer cell growth (human and murine) inhibitory (GI50 0.3 to 3.3 μg/ml) cyclo-octapeptide axinastatin 5 (2) was isolated in 3.8 x 10-7% yield from the Western Indian Ocean marine sponge Axinella cf. carteri. Structural elucidation was achieved by high field (400 and 500 MHz) 2 D-NMR techniques and the amino acid sequence was confirmed by results of NMR and high resolution mass spectral MS/MS interpretations. Other peptide cancer cell growth inhibitory constituents of this orange sponge were found to be the cyclic hepta- and octapeptides axinastatin 1 and hymenistatin 1 (1).

UR - http://www.scopus.com/inward/record.url?scp=0028595894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028595894&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(01)80843-X

DO - 10.1016/S0960-894X(01)80843-X

M3 - Article

VL - 4

SP - 2935

EP - 2940

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 24

ER -