Isolation and identification of a novel human metabolite of cyclosporin A

Dihydro-CsA M17

G. P. Meier, S. B. Park, Gary C Yee, D. J. Gmur

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A novel metabolite of cyclosporin A was observed in human blood and urine. An analytical sample of this metabolite was isolated from human urine and the structure was determined to be (8-hydroxy-6,7-dihydro-MeBMT1) cyclosporin based on the 1H-NMR, 13C-NMR, FAB-MS, adn HPLC characteristics of the biological sample as well as by comparison with a synthetically derived authentic sample. The significance of this metabolite in terms of the pathway by which cyclosporin A is metabolized is discussed.

Original languageEnglish (US)
Pages (from-to)68-71
Number of pages4
JournalDrug Metabolism and Disposition
Volume18
Issue number1
StatePublished - Mar 14 1990

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Metabolites
Cyclosporine
Nuclear magnetic resonance
Urine
Blood
High Pressure Liquid Chromatography
8-hydroxy-6,7-dihydro-(4-(2-butenyl)-4,N-dimethylthreonine)cyclosporin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Isolation and identification of a novel human metabolite of cyclosporin A : Dihydro-CsA M17. / Meier, G. P.; Park, S. B.; Yee, Gary C; Gmur, D. J.

In: Drug Metabolism and Disposition, Vol. 18, No. 1, 14.03.1990, p. 68-71.

Research output: Contribution to journalArticle

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