Ischemia, reactive radicals, redox signaling and hematopoietic stem cells

Suman Kanji, Vincent J. Pompili, Hiranmoy Das

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Ischemia is a medical condition generated by inadequate or no blood flow to the organs such as heart, brain, limbs and kidney, contributes to the pathophysiology of several diseases such as myocardial infarction, cerebral ischemia (stroke), peripheral vascular insufficiency and hypovolemic shock etc. As a result of ischemic insult, cascades of metabolic and ultra structural changes occur at the cellular level resulted in irreversible tissue injury and cell death. Several pharmacological interventions such as antioxidant therapy, anti-inflammatory therapy along with reperfusion strategies have been tried for several decades to protect the affected tissue from necrosis and cell death after ischemic insult. But, none of these interventions had proven to be cure for ischemia. Thus, novel therapeutic approach such as stem cell becomes very popular in the field of regenerative medicine to treat post ischemic conditions and to improve patient lifestyle as an alternate. Hematopoietic stem and progenitor cells from different sources showed promise to the ischemic therapy. Human umbilical cord blood-derived stem cells are one of the most promising cells that have shown beneficial effects in treating ischemic disorders in pre-clinical models and some clinical trials. However, several hurdles such as adequate supply of stem cells, suitable route of administration, need to be addressed to use as a regular therapeutic regiment for ischemic patients in the clinic.

Original languageEnglish (US)
Title of host publicationStem Cells and Human Diseases
PublisherSpringer Netherlands
Pages197-216
Number of pages20
Volume9789400728011
ISBN (Electronic)9789400728011
ISBN (Print)940072800X, 9789400728004
DOIs
Publication statusPublished - Apr 1 2012

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Keywords

  • Hematopoietic stem cells
  • Leukemia
  • Redox signaling
  • Stem cell therapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kanji, S., Pompili, V. J., & Das, H. (2012). Ischemia, reactive radicals, redox signaling and hematopoietic stem cells. In Stem Cells and Human Diseases (Vol. 9789400728011, pp. 197-216). Springer Netherlands. https://doi.org/10.1007/978-94-007-2801-1_9