IPMN Involving the Main Pancreatic Duct

Biology, Epidemiology, and Long-term Outcomes Following Resection

Giovanni Marchegiani, Mari Mino-Kenudson, Klaus Sahora, Vicente Morales-Oyarvide, Sarah P Thayer, Cristina Ferrone, Andrew L. Warshaw, Keith D. Lillemoe, Carlos Fernández Del Castillo

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Objectives: To describe the characteristics of intraductal papillary mucinous neoplasms (IPMNs) with predominant involvement of the main pancreatic duct (MPD), analyzing predictors for survival and recurrence. Background: IPMNs involving the MPD harbor a high likelihood of malignancy and different biological features. The appropriateness of including cases with minimal noncircumferential MPD involvement has been challenged because these show clinicopathological features that are similar to branch duct IPMN. Accordingly, their exclusion has led to a redefinition of MPD IPMN (MD-IPMN). Methods: Retrospective review of resected MD-IPMN from 1990 to 2013. All slides were reviewed by a single pancreatic pathologist and classified on the basis of epithelial type and invasive component. Results: A total of 223 patients underwent resection for IPMN involving the MPD. Of these, 50 were excluded because of minimal MPD involvement. Among the 173 patients analyzed, median age was 68 years and 55% were males. Predominant epithelial phenotype was intestinal (50%). Forty-eight patients (28%) had low-or intermediate-grade dysplasia, whereas 125 (72%) had either high-grade dysplasia (33%) or invasive carcinoma (39%). Of the 67 invasive IPMNs, 39 were tubular carcinomas (58%) and invasion was minimal (

Original languageEnglish (US)
Pages (from-to)976-983
Number of pages8
JournalAnnals of Surgery
Volume261
Issue number5
DOIs
StatePublished - May 1 2015
Externally publishedYes

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Pancreatic Ducts
Epidemiology
Neoplasms
Adenocarcinoma
Carcinoma
Phenotype
Recurrence
Survival

Keywords

  • cystic neoplasm
  • intraductal papillary mucinous neoplasm
  • IPMN
  • MD-IPMN
  • pancreas

ASJC Scopus subject areas

  • Surgery

Cite this

Marchegiani, G., Mino-Kenudson, M., Sahora, K., Morales-Oyarvide, V., Thayer, S. P., Ferrone, C., ... Castillo, C. F. D. (2015). IPMN Involving the Main Pancreatic Duct: Biology, Epidemiology, and Long-term Outcomes Following Resection. Annals of Surgery, 261(5), 976-983. https://doi.org/10.1097/SLA.0000000000000813

IPMN Involving the Main Pancreatic Duct : Biology, Epidemiology, and Long-term Outcomes Following Resection. / Marchegiani, Giovanni; Mino-Kenudson, Mari; Sahora, Klaus; Morales-Oyarvide, Vicente; Thayer, Sarah P; Ferrone, Cristina; Warshaw, Andrew L.; Lillemoe, Keith D.; Castillo, Carlos Fernández Del.

In: Annals of Surgery, Vol. 261, No. 5, 01.05.2015, p. 976-983.

Research output: Contribution to journalArticle

Marchegiani, G, Mino-Kenudson, M, Sahora, K, Morales-Oyarvide, V, Thayer, SP, Ferrone, C, Warshaw, AL, Lillemoe, KD & Castillo, CFD 2015, 'IPMN Involving the Main Pancreatic Duct: Biology, Epidemiology, and Long-term Outcomes Following Resection', Annals of Surgery, vol. 261, no. 5, pp. 976-983. https://doi.org/10.1097/SLA.0000000000000813
Marchegiani, Giovanni ; Mino-Kenudson, Mari ; Sahora, Klaus ; Morales-Oyarvide, Vicente ; Thayer, Sarah P ; Ferrone, Cristina ; Warshaw, Andrew L. ; Lillemoe, Keith D. ; Castillo, Carlos Fernández Del. / IPMN Involving the Main Pancreatic Duct : Biology, Epidemiology, and Long-term Outcomes Following Resection. In: Annals of Surgery. 2015 ; Vol. 261, No. 5. pp. 976-983.
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