Ion channels in mesangial cells: Function, malfunction, or fiction

Rong Ma, Jennifer L. Pluznick, Steven C. Sansom

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Ion channels in glomerular mesangial cells from humans, rats, and mice have been studied by electrophysiological, molecular, and gene-knockout methods. Two channels, a large, Ca2+-activated K+ channel (BK) and a store-operated Ca2+ channel (SOCC), can be defined with respect to molecular structure and function. Human BK, comprised of a pore-forming α-subunit and an accessory β1-subunit, operate as Ca 2+-sensing feedback modulators of contractile tone. SOCC have also been characterized in a mouse cell line; they are comprised of molecules belonging to the transient receptor potential subfamily.

Original languageEnglish (US)
Pages (from-to)102-111
Number of pages10
JournalPhysiology
Volume20
Issue number2
DOIs
StatePublished - Apr 2005

Fingerprint

Mesangial Cells
Ion Channels
Calcium-Activated Potassium Channels
Gene Knockout Techniques
Molecular Structure
Cell Line

ASJC Scopus subject areas

  • Physiology

Cite this

Ion channels in mesangial cells : Function, malfunction, or fiction. / Ma, Rong; Pluznick, Jennifer L.; Sansom, Steven C.

In: Physiology, Vol. 20, No. 2, 04.2005, p. 102-111.

Research output: Contribution to journalReview article

Ma, Rong ; Pluznick, Jennifer L. ; Sansom, Steven C. / Ion channels in mesangial cells : Function, malfunction, or fiction. In: Physiology. 2005 ; Vol. 20, No. 2. pp. 102-111.
@article{a98fe0eb2ce141de8e993ca30962fc3d,
title = "Ion channels in mesangial cells: Function, malfunction, or fiction",
abstract = "Ion channels in glomerular mesangial cells from humans, rats, and mice have been studied by electrophysiological, molecular, and gene-knockout methods. Two channels, a large, Ca2+-activated K+ channel (BK) and a store-operated Ca2+ channel (SOCC), can be defined with respect to molecular structure and function. Human BK, comprised of a pore-forming α-subunit and an accessory β1-subunit, operate as Ca 2+-sensing feedback modulators of contractile tone. SOCC have also been characterized in a mouse cell line; they are comprised of molecules belonging to the transient receptor potential subfamily.",
author = "Rong Ma and Pluznick, {Jennifer L.} and Sansom, {Steven C.}",
year = "2005",
month = "4",
doi = "10.1152/physiol.00050.2004",
language = "English (US)",
volume = "20",
pages = "102--111",
journal = "Physiology",
issn = "1548-9213",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - Ion channels in mesangial cells

T2 - Function, malfunction, or fiction

AU - Ma, Rong

AU - Pluznick, Jennifer L.

AU - Sansom, Steven C.

PY - 2005/4

Y1 - 2005/4

N2 - Ion channels in glomerular mesangial cells from humans, rats, and mice have been studied by electrophysiological, molecular, and gene-knockout methods. Two channels, a large, Ca2+-activated K+ channel (BK) and a store-operated Ca2+ channel (SOCC), can be defined with respect to molecular structure and function. Human BK, comprised of a pore-forming α-subunit and an accessory β1-subunit, operate as Ca 2+-sensing feedback modulators of contractile tone. SOCC have also been characterized in a mouse cell line; they are comprised of molecules belonging to the transient receptor potential subfamily.

AB - Ion channels in glomerular mesangial cells from humans, rats, and mice have been studied by electrophysiological, molecular, and gene-knockout methods. Two channels, a large, Ca2+-activated K+ channel (BK) and a store-operated Ca2+ channel (SOCC), can be defined with respect to molecular structure and function. Human BK, comprised of a pore-forming α-subunit and an accessory β1-subunit, operate as Ca 2+-sensing feedback modulators of contractile tone. SOCC have also been characterized in a mouse cell line; they are comprised of molecules belonging to the transient receptor potential subfamily.

UR - http://www.scopus.com/inward/record.url?scp=18244378538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18244378538&partnerID=8YFLogxK

U2 - 10.1152/physiol.00050.2004

DO - 10.1152/physiol.00050.2004

M3 - Review article

C2 - 15772299

AN - SCOPUS:18244378538

VL - 20

SP - 102

EP - 111

JO - Physiology

JF - Physiology

SN - 1548-9213

IS - 2

ER -