Involvement ofmiR-9/MCPIP1 axis in PDGF-BB-mediated neurogenesis in neuronal progenitor cells

L. Yang, J. Chao, Y. H. Kook, Y. Gao, H. Yao, Shilpa J Buch

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Highly conserved microRNA-9 (miR-9) has a critical role in various cellular processes including neurogenesis. However, its regulation by neurotropins that are known to mediate neurogenesis remains poorly defined. In this study, we identify plateletderived growth factor-BB (PDGF-BB)-mediated upregulation of miR-9, which in turn downregulates its target gene monocyte chemotactic protein-induced protein 1 (MCPIP1), as a key player in modulating proliferation, neuronal differentiation as well as migration of neuronal progenitor cells (NPCs). Results indicate that miR-9-mediated NPC proliferation and neuronal differentiation involves signaling via the nuclear factor-kappa B (NF-κB) and cAMP response element-binding protein (CREB) pathways, and that NPC migration involves CREB but not the NF-κB signaling. These findings thus suggest that miR-9-mediated downregulation of MCPIP1 acts as a molecular switch regulation of neurogenesis.

Original languageEnglish (US)
Article numbere960
JournalCell Death and Disease
Volume4
Issue number12
DOIs
StatePublished - Dec 1 2013

Fingerprint

Monocyte Chemoattractant Proteins
Neurogenesis
MicroRNAs
Intercellular Signaling Peptides and Proteins
Stem Cells
Cyclic AMP Response Element-Binding Protein
NF-kappa B
Proteins
Down-Regulation
Cell Movement
Up-Regulation
Cell Proliferation
Genes

Keywords

  • MCPIP1
  • PDGF-BB
  • miR-9
  • neurogenesis
  • neuronal progenitor cell

ASJC Scopus subject areas

  • Immunology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Cancer Research

Cite this

Involvement ofmiR-9/MCPIP1 axis in PDGF-BB-mediated neurogenesis in neuronal progenitor cells. / Yang, L.; Chao, J.; Kook, Y. H.; Gao, Y.; Yao, H.; Buch, Shilpa J.

In: Cell Death and Disease, Vol. 4, No. 12, e960, 01.12.2013.

Research output: Contribution to journalArticle

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AU - Chao, J.

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AU - Yao, H.

AU - Buch, Shilpa J

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