Investigation of ligand-receptor systems by high-resolution solid-state NMR

Recent progress and perspectives

Sorin M Luca, Henrike Heise, Adam Lange, Marc Baldus

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Solid-state Nuclear Magnetic Resonance (NMR) provides a general method to study molecular structure and dynamics in a non-crystalline and insoluble environment. We discuss the latest methodological progress to construct 3D molecular structures from solid-state NMR data obtained under magic-angle-spinning conditions. As shown for the neurotensin/NTS-1 system, these methods can be readily applied to the investigation of ligand-binding to G-protein coupled receptors.

Original languageEnglish (US)
Pages (from-to)217-228
Number of pages12
JournalArchiv der Pharmazie
Volume338
Issue number5-6
DOIs
StatePublished - Jun 1 2005

Fingerprint

Molecular structure
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Ligands
Molecular Conformation
Neurotensin
Magic angle spinning
Molecular Dynamics Simulation
G-Protein-Coupled Receptors
Molecular Structure
Molecular dynamics

Keywords

  • GPCR
  • Ligand
  • MAS
  • NMR
  • Solid state

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

Cite this

Investigation of ligand-receptor systems by high-resolution solid-state NMR : Recent progress and perspectives. / Luca, Sorin M; Heise, Henrike; Lange, Adam; Baldus, Marc.

In: Archiv der Pharmazie, Vol. 338, No. 5-6, 01.06.2005, p. 217-228.

Research output: Contribution to journalReview article

Luca, Sorin M ; Heise, Henrike ; Lange, Adam ; Baldus, Marc. / Investigation of ligand-receptor systems by high-resolution solid-state NMR : Recent progress and perspectives. In: Archiv der Pharmazie. 2005 ; Vol. 338, No. 5-6. pp. 217-228.
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