Investigation of effectiveness of microbubble stable cavitation in thrombolysis

William T. Shi, Shunji Gao, Vignon Francois, Jeff E. Powers, Lucas Drvol, Ki Won Jung, Feng Xie, John Lof, E. Carr Everbach, Thomas Richard Porter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Ultrasound and intravenous microbubbles have been used in recanalizing intravascular thrombi which cause ischemic stroke, myocardial infarction, and other vascular thrombo-embolic events. In previous studies, inertial cavitation (IC) produced by high mechanical index (MI) ultrasound has been shown to be effective in dissolving acute thrombi. However, IC is more likely to cause adverse bioeffects than stable cavitation (SC). This study indicates that SC induced by intermediate MI ultrasound (1.6 MHz, 0.35 MI, 50 cycles) is as effective for acute thrombus dissolution as IC by high MI ultrasound (1.6 MHz, 1.1 MI, 2.5 cycles).

Original languageEnglish (US)
Title of host publication2010 IEEE International Ultrasonics Symposium, IUS 2010
Pages330-333
Number of pages4
DOIs
StatePublished - Dec 1 2010
Event2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States
Duration: Oct 11 2010Oct 14 2010

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117

Conference

Conference2010 IEEE International Ultrasonics Symposium, IUS 2010
CountryUnited States
CitySan Diego, CA
Period10/11/1010/14/10

Fingerprint

cavitation flow
dissolving
myocardial infarction
cycles
causes
strokes

Keywords

  • microbubbles
  • sonothrombolysis
  • ultrasound therapy

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Shi, W. T., Gao, S., Francois, V., Powers, J. E., Drvol, L., Jung, K. W., ... Porter, T. R. (2010). Investigation of effectiveness of microbubble stable cavitation in thrombolysis. In 2010 IEEE International Ultrasonics Symposium, IUS 2010 (pp. 330-333). [5935628] (Proceedings - IEEE Ultrasonics Symposium). https://doi.org/10.1109/ULTSYM.2010.5935628

Investigation of effectiveness of microbubble stable cavitation in thrombolysis. / Shi, William T.; Gao, Shunji; Francois, Vignon; Powers, Jeff E.; Drvol, Lucas; Jung, Ki Won; Xie, Feng; Lof, John; Everbach, E. Carr; Porter, Thomas Richard.

2010 IEEE International Ultrasonics Symposium, IUS 2010. 2010. p. 330-333 5935628 (Proceedings - IEEE Ultrasonics Symposium).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shi, WT, Gao, S, Francois, V, Powers, JE, Drvol, L, Jung, KW, Xie, F, Lof, J, Everbach, EC & Porter, TR 2010, Investigation of effectiveness of microbubble stable cavitation in thrombolysis. in 2010 IEEE International Ultrasonics Symposium, IUS 2010., 5935628, Proceedings - IEEE Ultrasonics Symposium, pp. 330-333, 2010 IEEE International Ultrasonics Symposium, IUS 2010, San Diego, CA, United States, 10/11/10. https://doi.org/10.1109/ULTSYM.2010.5935628
Shi WT, Gao S, Francois V, Powers JE, Drvol L, Jung KW et al. Investigation of effectiveness of microbubble stable cavitation in thrombolysis. In 2010 IEEE International Ultrasonics Symposium, IUS 2010. 2010. p. 330-333. 5935628. (Proceedings - IEEE Ultrasonics Symposium). https://doi.org/10.1109/ULTSYM.2010.5935628
Shi, William T. ; Gao, Shunji ; Francois, Vignon ; Powers, Jeff E. ; Drvol, Lucas ; Jung, Ki Won ; Xie, Feng ; Lof, John ; Everbach, E. Carr ; Porter, Thomas Richard. / Investigation of effectiveness of microbubble stable cavitation in thrombolysis. 2010 IEEE International Ultrasonics Symposium, IUS 2010. 2010. pp. 330-333 (Proceedings - IEEE Ultrasonics Symposium).
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