Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species

Peter Charles Iwen, Stephanie D. Schutte, Diana F Florescu, Rhonda K. Noel-Hurst, Lynne Sigler

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Scopulariopsis species and their Microascus teleomorphs are cosmopolitan fungi that are uncommonly associated with invasive disease. This report describes a case of fatal disseminated Scopulariopsis brevicaulis disease in a patient with diffuse large B cell lymphoma who underwent high-dose chemotherapy followed by a matched unrelated donor stem cell transplant. This case is compared with 32 prior cases of proven invasive Scopulariopsis (Microascus) infections reported in the literature. A focus of this report is the diagnostic methods utilized which included histopathology and culture with both micromorphologic and genotypic procedures employed to confirm the species identification.

Original languageEnglish (US)
Pages (from-to)561-569
Number of pages9
JournalMedical Mycology
Volume50
Issue number6
DOIs
StatePublished - Aug 1 2012

Fingerprint

Scopulariopsis
Immunocompromised Host
Infection
infection
teleomorphs
Unrelated Donors
Lymphoma, Large B-Cell, Diffuse
lymphoma
histopathology
diagnostic techniques
drug therapy
B-lymphocytes
stem cells
Fungi
Stem Cells
case studies
Transplants
Drug Therapy
fungi
dosage

Keywords

  • Genomic
  • Histopathology
  • Internal transcribed spacer region
  • Invasive mold
  • Microascus
  • Scopulariopsis brevicaulis

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species. / Iwen, Peter Charles; Schutte, Stephanie D.; Florescu, Diana F; Noel-Hurst, Rhonda K.; Sigler, Lynne.

In: Medical Mycology, Vol. 50, No. 6, 01.08.2012, p. 561-569.

Research output: Contribution to journalReview article

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