Abstract

A 12-year retrospective analysis was done to identify and evaluate in detail cases of invasive pulmonary aspergillosis (IPA) caused by Aspergillus terreus. We identified 13 A. terreus infections among 133 total cases of confirmed invasive aspergillosis; 11 were IPA and 2 were primary peritoneal infections. Of the 11 patients with IPA, 7 developed neutropenia during hospitalization, and the remaining four were receiving immunosuppressive agents. Ten patients with IPA died; one liver transplantation patient without neutropenia survived after treatment with amphotericin B, itraconazole, and a pulmonary lobectomy. Six patients developed disseminated disease, with the heart the most common extrapulmonary site identified (four patients). These cases demonstrate that IPA caused by A. terreus rapidly progresses in immunocompromised patients receiving amphotericin B and illustrate the need for sensitive diagnostic tests and more effective antifungal agents.

Original languageEnglish (US)
Pages (from-to)1092-1097
Number of pages6
JournalClinical Infectious Diseases
Volume26
Issue number5
DOIs
StatePublished - Jan 1 1998

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Invasive Pulmonary Aspergillosis
Aspergillus
Amphotericin B
Neutropenia
Itraconazole
Aspergillosis
Antifungal Agents
Immunocompromised Host
Immunosuppressive Agents
Infection
Routine Diagnostic Tests
Liver Transplantation
Heart Diseases
Hospitalization
Lung

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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title = "Invasive pulmonary aspergillosis due to Aspergillus terreus: 12-year experience and review of the literature",
abstract = "A 12-year retrospective analysis was done to identify and evaluate in detail cases of invasive pulmonary aspergillosis (IPA) caused by Aspergillus terreus. We identified 13 A. terreus infections among 133 total cases of confirmed invasive aspergillosis; 11 were IPA and 2 were primary peritoneal infections. Of the 11 patients with IPA, 7 developed neutropenia during hospitalization, and the remaining four were receiving immunosuppressive agents. Ten patients with IPA died; one liver transplantation patient without neutropenia survived after treatment with amphotericin B, itraconazole, and a pulmonary lobectomy. Six patients developed disseminated disease, with the heart the most common extrapulmonary site identified (four patients). These cases demonstrate that IPA caused by A. terreus rapidly progresses in immunocompromised patients receiving amphotericin B and illustrate the need for sensitive diagnostic tests and more effective antifungal agents.",
author = "Iwen, {Peter Charles} and Rupp, {Mark Edmund} and Langnas, {Alan Norman} and Reed, {Elizabeth Cecile} and Hinrichs, {Steven Heye}",
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AU - Iwen, Peter Charles

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AU - Langnas, Alan Norman

AU - Reed, Elizabeth Cecile

AU - Hinrichs, Steven Heye

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