Invasive non-typhoidal Salmonella in sickle cell disease in Africa: Is increased gut permeability the missing link?

Seah H. Lim, Barbara A. Methé, Bettina M. Knoll, Alison Morris, Stephen K Obaro

Research output: Contribution to journalComment/debate

3 Scopus citations

Abstract

Non-typhoidal Salmonella usually induces self-limiting gastroenteritis. However, in many parts of Africa, especially in individuals who are malnourished, infected with malaria, or have sickle cell disease, the organism causes serious and potentially fatal systemic infections. Since the portal of entry of non-typhoidal Salmonella into the systemic circulation is by way of the intestine, we argue that an increased gut permeability plays a vital role in the initiation of invasive non-typhoidal Salmonella in these patients. Here, we will appraise the evidence supporting a breach in the intestinal barrier and propose the mechanisms for the increased risks for invasive non-typhoidal Salmonella infections in these individuals.

Original languageEnglish (US)
Article number239
JournalJournal of Translational Medicine
Volume16
Issue number1
DOIs
Publication statusPublished - Aug 30 2018

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Keywords

  • Gut permeability
  • Intestinal dysbiosis
  • Invasive non-typhoidal Salmonella
  • Sickle cell disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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