Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006

Benjamin J. Park, Peter G. Pappas, Kathleen A. Wannemuehler, Barbara D. Alexander, Elias J. Anaissie, David R. Andes, John W. Baddley, Janice M. Brown, Lisa M. Brumble, Alison Gail Freifeld, Susan Hadley, Loreen Herwaldt, James I. Ito, Carol A. Kauffman, G. Marshall Lyon, Kieren A. Marr, Vicki A. Morrison, Genovefa Papanicolaou, Thomas F. Patterson, Trish M. PerlMindy G. Schuster, Randall Walker, John R. Wingard, Thomas J. Walsh, Dimitrios P. Kontoyiannis

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Recent reports describe increasing incidence of non- Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identifled 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.

Original languageEnglish (US)
Pages (from-to)1855-1864
Number of pages10
JournalEmerging infectious diseases
Volume17
Issue number10
DOIs
StatePublished - Oct 2011

Fingerprint

Fungi
Transplants
Infection
Mucormycosis
Mucorales
Scedosporium
Incidence
Fusarium
Transplant Recipients
Mortality
Aspergillus
Epidemiology

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Park, B. J., Pappas, P. G., Wannemuehler, K. A., Alexander, B. D., Anaissie, E. J., Andes, D. R., ... Kontoyiannis, D. P. (2011). Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006. Emerging infectious diseases, 17(10), 1855-1864. https://doi.org/10.3201/eid1710.110087

Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006. / Park, Benjamin J.; Pappas, Peter G.; Wannemuehler, Kathleen A.; Alexander, Barbara D.; Anaissie, Elias J.; Andes, David R.; Baddley, John W.; Brown, Janice M.; Brumble, Lisa M.; Freifeld, Alison Gail; Hadley, Susan; Herwaldt, Loreen; Ito, James I.; Kauffman, Carol A.; Lyon, G. Marshall; Marr, Kieren A.; Morrison, Vicki A.; Papanicolaou, Genovefa; Patterson, Thomas F.; Perl, Trish M.; Schuster, Mindy G.; Walker, Randall; Wingard, John R.; Walsh, Thomas J.; Kontoyiannis, Dimitrios P.

In: Emerging infectious diseases, Vol. 17, No. 10, 10.2011, p. 1855-1864.

Research output: Contribution to journalArticle

Park, BJ, Pappas, PG, Wannemuehler, KA, Alexander, BD, Anaissie, EJ, Andes, DR, Baddley, JW, Brown, JM, Brumble, LM, Freifeld, AG, Hadley, S, Herwaldt, L, Ito, JI, Kauffman, CA, Lyon, GM, Marr, KA, Morrison, VA, Papanicolaou, G, Patterson, TF, Perl, TM, Schuster, MG, Walker, R, Wingard, JR, Walsh, TJ & Kontoyiannis, DP 2011, 'Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006', Emerging infectious diseases, vol. 17, no. 10, pp. 1855-1864. https://doi.org/10.3201/eid1710.110087
Park BJ, Pappas PG, Wannemuehler KA, Alexander BD, Anaissie EJ, Andes DR et al. Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006. Emerging infectious diseases. 2011 Oct;17(10):1855-1864. https://doi.org/10.3201/eid1710.110087
Park, Benjamin J. ; Pappas, Peter G. ; Wannemuehler, Kathleen A. ; Alexander, Barbara D. ; Anaissie, Elias J. ; Andes, David R. ; Baddley, John W. ; Brown, Janice M. ; Brumble, Lisa M. ; Freifeld, Alison Gail ; Hadley, Susan ; Herwaldt, Loreen ; Ito, James I. ; Kauffman, Carol A. ; Lyon, G. Marshall ; Marr, Kieren A. ; Morrison, Vicki A. ; Papanicolaou, Genovefa ; Patterson, Thomas F. ; Perl, Trish M. ; Schuster, Mindy G. ; Walker, Randall ; Wingard, John R. ; Walsh, Thomas J. ; Kontoyiannis, Dimitrios P. / Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006. In: Emerging infectious diseases. 2011 ; Vol. 17, No. 10. pp. 1855-1864.
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