Invasive group A streptococcal infections in children.

Herbert Dele Davies, B. Schwartz

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Invasive group A streptococcal infections and STSS have increased as causes of morbidity and mortality among children and adults. In children, respiratory foci appear to be the most common, but skin and soft tissue infection, particularly associated with varicella, also are common. Early diagnosis requires awareness of the presenting features and a high index of suspicion. Antimicrobial therapy that includes clindamycin, therapy with IVIG for those with STSS, and surgical intervention for patients with necrotizing fasciitis may improve outcome. Chemoprophylaxis should be considered among household contacts of patients with severe group A streptococcal disease in high-risk settings. Further studies are ongoing to evaluate the hypothesized link of invasive group A streptococcal infection in children with varicella and NSAID use, to better clarify the pathogenesis of STSS and necrotizing fasciitis, and to better document the risk of secondary spread among close contacts of case patients.

Original languageEnglish (US)
Pages (from-to)129-145
Number of pages17
JournalAdvances in pediatric infectious diseases
Volume14
StatePublished - Jan 1 1999

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Streptococcal Infections
Necrotizing Fasciitis
Chickenpox
Child Mortality
Soft Tissue Infections
Clindamycin
Intravenous Immunoglobulins
Chemoprevention
Non-Steroidal Anti-Inflammatory Agents
Early Diagnosis
Morbidity
Skin
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Invasive group A streptococcal infections in children. / Davies, Herbert Dele; Schwartz, B.

In: Advances in pediatric infectious diseases, Vol. 14, 01.01.1999, p. 129-145.

Research output: Contribution to journalReview article

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