Invasive candidiasis in low birth weight preterm infants: Risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls

Michelle Barton, Karel O'Brien, Joan L. Robinson, Dele H. Davies, Kim Simpson, Elizabeth Asztalos, Joanne M. Langley, Nicole Le Saux, Reg Sauve, Anne Synnes, Ben Tan, Louis de Repentigny, Earl Rubin, Chuck Hui, Lajos Kovacs, Susan E. Richardson

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Abstract

Background: This multicenter prospective study of invasive candidiasis (IC) was carried out to determine the risk factors for, incidence of, clinical and laboratory features, treatment and outcome of IC in infants of birth weight <1250 g.Methods: Neonates <1250 g with IC and their matched controls (2:1) were followed longitudinally and descriptive analysis was performed. Survivors underwent neurodevelopmental assessment at 18 to 24 months corrected age. Neurodevelopmental impairment (NDI) was defined as blindness, deafness, moderate to severe cerebral palsy, or a score <70 on the Bayley Scales of Infant Development 2nd edition. Multivariable analyses were performed to determine risk factors for IC and predictors of mortality and NDI.Results: Cumulative incidence rates of IC were 4.2%, 2.2% and 1.5% for birth-weight categories <750 g, <1000 g, <1500 g, respectively. Forty nine infants with IC and 90 controls were enrolled. Necrotizing enterocolitis (NEC) was the only independent risk factor for IC (p = 0.03). CNS candidiasis occurred in 50% of evaluated infants, while congenital candidiasis occurred in 31%. Infants with CNS candidiasis had a higher mortality rate (57%) and incidence of deafness (50%) than the overall cohort of infants with IC. NDI (56% vs. 33%; p = 0.017) and death (45% vs. 7%; p = 0.0001) were more likely in cases than in controls, respectively. IC survivors were more likely to be deaf (28% vs. 7%; p = 0.01). IC independently predicted mortality (p = 0.0004) and NDI (p = 0.018).Conclusion: IC occurred in 1.5% of VLBW infants. Preceding NEC increased the risk of developing IC. CNS candidiasis is under-investigated and difficult to diagnose, but portends a very poor outcome. Mortality, deafness and NDI were independently significantly increased in infants with IC compared to matched controls.

Original languageEnglish (US)
Article number327
JournalBMC Infectious Diseases
Volume14
Issue number1
DOIs
StatePublished - Jun 12 2014

Fingerprint

Invasive Candidiasis
Low Birth Weight Infant
Premature Infants
Multicenter Studies
Prospective Studies
Candidiasis
Necrotizing Enterocolitis
Mortality
Deafness
Birth Weight
Survivors
Incidence
Deaf-Blind Disorders
Cerebral Palsy
Child Development

Keywords

  • Invasive candidiasis
  • Neonatal
  • Neurodevelopmental outcome
  • Prematurity
  • Risk factors

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Invasive candidiasis in low birth weight preterm infants : Risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls. / Barton, Michelle; O'Brien, Karel; Robinson, Joan L.; Davies, Dele H.; Simpson, Kim; Asztalos, Elizabeth; Langley, Joanne M.; Le Saux, Nicole; Sauve, Reg; Synnes, Anne; Tan, Ben; de Repentigny, Louis; Rubin, Earl; Hui, Chuck; Kovacs, Lajos; Richardson, Susan E.

In: BMC Infectious Diseases, Vol. 14, No. 1, 327, 12.06.2014.

Research output: Contribution to journalArticle

Barton, M, O'Brien, K, Robinson, JL, Davies, DH, Simpson, K, Asztalos, E, Langley, JM, Le Saux, N, Sauve, R, Synnes, A, Tan, B, de Repentigny, L, Rubin, E, Hui, C, Kovacs, L & Richardson, SE 2014, 'Invasive candidiasis in low birth weight preterm infants: Risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls', BMC Infectious Diseases, vol. 14, no. 1, 327. https://doi.org/10.1186/1471-2334-14-327
Barton, Michelle ; O'Brien, Karel ; Robinson, Joan L. ; Davies, Dele H. ; Simpson, Kim ; Asztalos, Elizabeth ; Langley, Joanne M. ; Le Saux, Nicole ; Sauve, Reg ; Synnes, Anne ; Tan, Ben ; de Repentigny, Louis ; Rubin, Earl ; Hui, Chuck ; Kovacs, Lajos ; Richardson, Susan E. / Invasive candidiasis in low birth weight preterm infants : Risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls. In: BMC Infectious Diseases. 2014 ; Vol. 14, No. 1.
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abstract = "Background: This multicenter prospective study of invasive candidiasis (IC) was carried out to determine the risk factors for, incidence of, clinical and laboratory features, treatment and outcome of IC in infants of birth weight <1250 g.Methods: Neonates <1250 g with IC and their matched controls (2:1) were followed longitudinally and descriptive analysis was performed. Survivors underwent neurodevelopmental assessment at 18 to 24 months corrected age. Neurodevelopmental impairment (NDI) was defined as blindness, deafness, moderate to severe cerebral palsy, or a score <70 on the Bayley Scales of Infant Development 2nd edition. Multivariable analyses were performed to determine risk factors for IC and predictors of mortality and NDI.Results: Cumulative incidence rates of IC were 4.2{\%}, 2.2{\%} and 1.5{\%} for birth-weight categories <750 g, <1000 g, <1500 g, respectively. Forty nine infants with IC and 90 controls were enrolled. Necrotizing enterocolitis (NEC) was the only independent risk factor for IC (p = 0.03). CNS candidiasis occurred in 50{\%} of evaluated infants, while congenital candidiasis occurred in 31{\%}. Infants with CNS candidiasis had a higher mortality rate (57{\%}) and incidence of deafness (50{\%}) than the overall cohort of infants with IC. NDI (56{\%} vs. 33{\%}; p = 0.017) and death (45{\%} vs. 7{\%}; p = 0.0001) were more likely in cases than in controls, respectively. IC survivors were more likely to be deaf (28{\%} vs. 7{\%}; p = 0.01). IC independently predicted mortality (p = 0.0004) and NDI (p = 0.018).Conclusion: IC occurred in 1.5{\%} of VLBW infants. Preceding NEC increased the risk of developing IC. CNS candidiasis is under-investigated and difficult to diagnose, but portends a very poor outcome. Mortality, deafness and NDI were independently significantly increased in infants with IC compared to matched controls.",
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T2 - Risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls

AU - Barton, Michelle

AU - O'Brien, Karel

AU - Robinson, Joan L.

AU - Davies, Dele H.

AU - Simpson, Kim

AU - Asztalos, Elizabeth

AU - Langley, Joanne M.

AU - Le Saux, Nicole

AU - Sauve, Reg

AU - Synnes, Anne

AU - Tan, Ben

AU - de Repentigny, Louis

AU - Rubin, Earl

AU - Hui, Chuck

AU - Kovacs, Lajos

AU - Richardson, Susan E.

PY - 2014/6/12

Y1 - 2014/6/12

N2 - Background: This multicenter prospective study of invasive candidiasis (IC) was carried out to determine the risk factors for, incidence of, clinical and laboratory features, treatment and outcome of IC in infants of birth weight <1250 g.Methods: Neonates <1250 g with IC and their matched controls (2:1) were followed longitudinally and descriptive analysis was performed. Survivors underwent neurodevelopmental assessment at 18 to 24 months corrected age. Neurodevelopmental impairment (NDI) was defined as blindness, deafness, moderate to severe cerebral palsy, or a score <70 on the Bayley Scales of Infant Development 2nd edition. Multivariable analyses were performed to determine risk factors for IC and predictors of mortality and NDI.Results: Cumulative incidence rates of IC were 4.2%, 2.2% and 1.5% for birth-weight categories <750 g, <1000 g, <1500 g, respectively. Forty nine infants with IC and 90 controls were enrolled. Necrotizing enterocolitis (NEC) was the only independent risk factor for IC (p = 0.03). CNS candidiasis occurred in 50% of evaluated infants, while congenital candidiasis occurred in 31%. Infants with CNS candidiasis had a higher mortality rate (57%) and incidence of deafness (50%) than the overall cohort of infants with IC. NDI (56% vs. 33%; p = 0.017) and death (45% vs. 7%; p = 0.0001) were more likely in cases than in controls, respectively. IC survivors were more likely to be deaf (28% vs. 7%; p = 0.01). IC independently predicted mortality (p = 0.0004) and NDI (p = 0.018).Conclusion: IC occurred in 1.5% of VLBW infants. Preceding NEC increased the risk of developing IC. CNS candidiasis is under-investigated and difficult to diagnose, but portends a very poor outcome. Mortality, deafness and NDI were independently significantly increased in infants with IC compared to matched controls.

AB - Background: This multicenter prospective study of invasive candidiasis (IC) was carried out to determine the risk factors for, incidence of, clinical and laboratory features, treatment and outcome of IC in infants of birth weight <1250 g.Methods: Neonates <1250 g with IC and their matched controls (2:1) were followed longitudinally and descriptive analysis was performed. Survivors underwent neurodevelopmental assessment at 18 to 24 months corrected age. Neurodevelopmental impairment (NDI) was defined as blindness, deafness, moderate to severe cerebral palsy, or a score <70 on the Bayley Scales of Infant Development 2nd edition. Multivariable analyses were performed to determine risk factors for IC and predictors of mortality and NDI.Results: Cumulative incidence rates of IC were 4.2%, 2.2% and 1.5% for birth-weight categories <750 g, <1000 g, <1500 g, respectively. Forty nine infants with IC and 90 controls were enrolled. Necrotizing enterocolitis (NEC) was the only independent risk factor for IC (p = 0.03). CNS candidiasis occurred in 50% of evaluated infants, while congenital candidiasis occurred in 31%. Infants with CNS candidiasis had a higher mortality rate (57%) and incidence of deafness (50%) than the overall cohort of infants with IC. NDI (56% vs. 33%; p = 0.017) and death (45% vs. 7%; p = 0.0001) were more likely in cases than in controls, respectively. IC survivors were more likely to be deaf (28% vs. 7%; p = 0.01). IC independently predicted mortality (p = 0.0004) and NDI (p = 0.018).Conclusion: IC occurred in 1.5% of VLBW infants. Preceding NEC increased the risk of developing IC. CNS candidiasis is under-investigated and difficult to diagnose, but portends a very poor outcome. Mortality, deafness and NDI were independently significantly increased in infants with IC compared to matched controls.

KW - Invasive candidiasis

KW - Neonatal

KW - Neurodevelopmental outcome

KW - Prematurity

KW - Risk factors

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