Invasion-specific genes in malignancy: Serial analysis of gene expression comparisons of primary and passaged cancers

B. Ryu, J. Jones, Michael A Hollingsworth, R. H. Hruban, S. E. Kern

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The invasive growth of malignant cells induces an admixture of host reactions including desmoplasia, angiogenesis, and immune reactions. Pancreatic cancer has a prominent and characteristic host reaction at the site of primary invasion. To obtain new insights into the process of tumor invasion, we studied global patterns of gene expression using serial analysis of gene expression in pancreatic cancer, with extension to other tumor types. Here we report a cluster of invasion-specific genes in pancreatic and other cancers. This cluster contains genes that derive from distinct components of the host reaction, including some that may be useful as diagnostic markers and therapeutic targets.

Original languageEnglish (US)
Pages (from-to)1833-1838
Number of pages6
JournalCancer Research
Volume61
Issue number5
StatePublished - Mar 1 2001

Fingerprint

Pancreatic Neoplasms
Gene Expression
Genes
Neoplasms
Multigene Family
Growth
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Invasion-specific genes in malignancy : Serial analysis of gene expression comparisons of primary and passaged cancers. / Ryu, B.; Jones, J.; Hollingsworth, Michael A; Hruban, R. H.; Kern, S. E.

In: Cancer Research, Vol. 61, No. 5, 01.03.2001, p. 1833-1838.

Research output: Contribution to journalArticle

@article{9504cf39ed1345efa5b36ec2cb29cbb2,
title = "Invasion-specific genes in malignancy: Serial analysis of gene expression comparisons of primary and passaged cancers",
abstract = "The invasive growth of malignant cells induces an admixture of host reactions including desmoplasia, angiogenesis, and immune reactions. Pancreatic cancer has a prominent and characteristic host reaction at the site of primary invasion. To obtain new insights into the process of tumor invasion, we studied global patterns of gene expression using serial analysis of gene expression in pancreatic cancer, with extension to other tumor types. Here we report a cluster of invasion-specific genes in pancreatic and other cancers. This cluster contains genes that derive from distinct components of the host reaction, including some that may be useful as diagnostic markers and therapeutic targets.",
author = "B. Ryu and J. Jones and Hollingsworth, {Michael A} and Hruban, {R. H.} and Kern, {S. E.}",
year = "2001",
month = "3",
day = "1",
language = "English (US)",
volume = "61",
pages = "1833--1838",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

TY - JOUR

T1 - Invasion-specific genes in malignancy

T2 - Serial analysis of gene expression comparisons of primary and passaged cancers

AU - Ryu, B.

AU - Jones, J.

AU - Hollingsworth, Michael A

AU - Hruban, R. H.

AU - Kern, S. E.

PY - 2001/3/1

Y1 - 2001/3/1

N2 - The invasive growth of malignant cells induces an admixture of host reactions including desmoplasia, angiogenesis, and immune reactions. Pancreatic cancer has a prominent and characteristic host reaction at the site of primary invasion. To obtain new insights into the process of tumor invasion, we studied global patterns of gene expression using serial analysis of gene expression in pancreatic cancer, with extension to other tumor types. Here we report a cluster of invasion-specific genes in pancreatic and other cancers. This cluster contains genes that derive from distinct components of the host reaction, including some that may be useful as diagnostic markers and therapeutic targets.

AB - The invasive growth of malignant cells induces an admixture of host reactions including desmoplasia, angiogenesis, and immune reactions. Pancreatic cancer has a prominent and characteristic host reaction at the site of primary invasion. To obtain new insights into the process of tumor invasion, we studied global patterns of gene expression using serial analysis of gene expression in pancreatic cancer, with extension to other tumor types. Here we report a cluster of invasion-specific genes in pancreatic and other cancers. This cluster contains genes that derive from distinct components of the host reaction, including some that may be useful as diagnostic markers and therapeutic targets.

UR - http://www.scopus.com/inward/record.url?scp=0035266179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035266179&partnerID=8YFLogxK

M3 - Article

C2 - 11280733

AN - SCOPUS:0035266179

VL - 61

SP - 1833

EP - 1838

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 5

ER -