Invasion of the P elements: Tolerance is not futile

Colin D. Meiklejohn, Justin P. Blumenstiel

Research output: Contribution to journalComment/debate

Abstract

Organisms are locked in an eternal struggle with parasitic DNA sequences that live inside their genomes and wreak havoc on their host's chromosomes as they spread through populations. To combat these parasites, host species have evolved elaborate mechanisms of resistance that suppress their activity. A new study in Drosophila indicates that, prior to the acquisition of resistance, individuals can vary in their ability to tolerate the activity of these genomic parasites, ignoring or repairing the damage they induce. This tolerance results from variation at genes involved in germline development and DNA damage checkpoints and suggests that these highly conserved cellular processes may be influenced by current and historical intragenomic parasite loads.

Original languageEnglish (US)
Pages (from-to)e3000036
JournalPLoS biology
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2018

Fingerprint

transposons
Parasites
Parasite Load
parasites
parasite load
Genes
resistance mechanisms
DNA damage
DNA Damage
Drosophila
germ cells
Chromosomes
DNA sequences
Genome
chromosomes
genomics
nucleotide sequences
genome
organisms
Population

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Invasion of the P elements : Tolerance is not futile. / Meiklejohn, Colin D.; Blumenstiel, Justin P.

In: PLoS biology, Vol. 16, No. 10, 01.10.2018, p. e3000036.

Research output: Contribution to journalComment/debate

Meiklejohn, Colin D. ; Blumenstiel, Justin P. / Invasion of the P elements : Tolerance is not futile. In: PLoS biology. 2018 ; Vol. 16, No. 10. pp. e3000036.
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