Intricacies of cardiac damage in coxsackievirus B3 infection

Implications for therapy

Chandirasegaran Massilamany, Arunakumar Gangaplara, N R Jayagopala Reddy

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Heart disease is the leading cause of death in humans, and myocarditis is one predominant cause of heart failure in young adults. Patients affected with myocarditis can develop dilated cardiomyopathy (DCM), a common reason for heart transplantation, which to date is the only viable option for combatting DCM. Myocarditis/DCM patients show antibodies to coxsackievirus B (CVB)3 and cardiac antigens, suggesting a role for CVB-mediated autoimmunity in the disease pathogenesis; however, a direct causal link remains to be determined clinically. Experimentally, myocarditis can be induced in susceptible strains of mice using the human isolates of CVB3, and the disease pathogenesis of postinfectious myocarditis resembles that of human disease, making the observations made in animals relevant to humans. In this review, we discuss the complex nature of CVB3-induced myocarditis as it relates to the damage caused by both the virus and the host's response to infection. Based on recent data we obtained in the mouse model of CVB3 infection, we provide evidence to suggest that CVB3 infection accompanies the generation of cardiac myosin-specific CD4 T cells that can transfer the disease to naïve recipients. The therapeutic implications of these observations are also discussed.

Original languageEnglish (US)
Pages (from-to)330-339
Number of pages10
JournalInternational Journal of Cardiology
Volume177
Issue number2
DOIs
StatePublished - Dec 15 2014

Fingerprint

Coxsackievirus Infections
Myocarditis
Dilated Cardiomyopathy
Human Enterovirus B
Therapeutics
Infection
Cardiac Myosins
Heart Transplantation
Autoimmunity
Young Adult
Cause of Death
Heart Diseases
Heart Failure
Viruses
T-Lymphocytes
Antigens
Antibodies

Keywords

  • Autoimmunity
  • Coxsackievirus
  • Heart
  • Viral myocarditis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Intricacies of cardiac damage in coxsackievirus B3 infection : Implications for therapy. / Massilamany, Chandirasegaran; Gangaplara, Arunakumar; Reddy, N R Jayagopala.

In: International Journal of Cardiology, Vol. 177, No. 2, 15.12.2014, p. 330-339.

Research output: Contribution to journalReview article

Massilamany, Chandirasegaran ; Gangaplara, Arunakumar ; Reddy, N R Jayagopala. / Intricacies of cardiac damage in coxsackievirus B3 infection : Implications for therapy. In: International Journal of Cardiology. 2014 ; Vol. 177, No. 2. pp. 330-339.
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