Intravaginal prostaglandin E 2 for cervical ripening and initiation of labor: Comparison of a multidose gel and single, controlled-release pessary

Carl Vernon Smith, W. F. Rayburn, A. M. Miller

Research output: Contribution to journalArticle

41 Scopus citations


A study was conducted to compare the efficacy and safety of two methods of delivering prostaglandin E 2 (PGE 2) as a low-dose gel delivered in up to two sequential, 2.5-mg doses and as a single-dose, controlled-release, 10-mg pessary. A cervical change was present in both groups, but a Bishop score ≥8 occurred in more nulliparous patients in the pessary than in the gel group by 12 hours after dosing. Labor was initiated without oxytocin more frequently in the pessary than gel group for nulliparas and multiparas. Reversal of uterine hyperstimulation was possible by removal of the pessary without tocolytic therapy. The controlled-release PGE 2 pessary was more effective in changing the cervix in nulliparas and in initiating labor and offered the advantage of removal when desired.

Original languageEnglish (US)
Pages (from-to)381-386
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number5
Publication statusPublished - Jun 10 1994



  • cervix uteri
  • dinoprostone
  • labor, induced

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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