Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons

Dao Qi Zhang, Kwoon Y. Wong, Patricia J Sollars, David M. Berson, Gary E Pickard, Douglas G. McMahon

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

Retinal dopaminergic amacrine neurons (DA neurons) play a central role in reconfiguring retinal function according to prevailing illumination conditions, yet the mechanisms by which light regulates their activity are poorly understood. We investigated the means by which sustained light responses are evoked in DA neurons. Sustained light responses were driven by cationic currents and persisted in vitro and in vivo in the presence of L-AP4, a blocker of retinal ON-bipolar cells. Several characteristics of these L-AP4-resistant light responses suggested that they were driven by melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), including long latencies, marked poststimulus persistence, and a peak spectral sensitivity of 478 nm. Furthermore, sustained DA neuron light responses, but not transient DA neuron responses, persisted in rod/cone degenerate retinas, in which ipRGCs account for virtually all remaining retinal phototransduction. Thus, ganglion-cell photoreceptors provide excitatory drive to DA neurons, most likely by way of the coramification of their dendrites and the processes of DA neurons in the inner plexiform layer. This unprecedented centrifugal outflow of ganglion-cell signals within the retina provides a novel basis for the restructuring of retinal circuits by light.

Original languageEnglish (US)
Pages (from-to)14181-14186
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue number37
DOIs
StatePublished - Sep 16 2008

Fingerprint

Photoreceptor Cells
Dopaminergic Neurons
Ganglia
Light
Retinal Ganglion Cells
Retinal Bipolar Cells
Light Signal Transduction
Retinal Cone Photoreceptor Cells
Retinal Neurons
Vertebrate Photoreceptor Cells
Dendrites
Lighting
Retina

Keywords

  • Adaptation
  • Dopamine
  • Melanopsin
  • Photoreception
  • Vision

ASJC Scopus subject areas

  • General

Cite this

Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons. / Zhang, Dao Qi; Wong, Kwoon Y.; Sollars, Patricia J; Berson, David M.; Pickard, Gary E; McMahon, Douglas G.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 37, 16.09.2008, p. 14181-14186.

Research output: Contribution to journalArticle

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