Intraductal papillary mucinous neoplasms: Does a family history of pancreatic cancer matter?

Deepika Nehra, Vicente Morales Oyarvide, Mari Mino-Kenudson, Sarah P. Thayer, Cristina R. Ferrone, Jennifer A. Wargo, Alona Muzikansky, Dianne Finkelstein, Andrew L. Warshawa, Carlos Fernández Del Castillo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background/Objectives: The purpose of this study is to compare surgically resected intraductal papillary mucinous neoplasms (IPMNs) in patients with and without a family history of pancreatic cancer to gain insight into differences that may suggest the need for differential management. Methods: A retrospective review of patients who underwent resection of an IPMN at the Massachusetts General Hospital (1990e2011) was conducted. Three hundred and twenty-four patients of whom 45 (13.9%) had a family history of pancreatic cancer were identified. Patients with (PFH) and without (NFH) a family history of pancreatic cancer were compared. Results: There were no differences in demographic characteristics between groups. Extra-pancreatic malignancies diagnosed prior to the IPMN were more common in those with a PFH (35.6% vs 20.1%, p = 0.03). There were no differences in IPMN characteristics between groups including no difference in the presence of invasive disease (p = 0.55). Concurrent pancreatic ductal adenocarcinomas were more common in those with a PFH (11.1% vs 2.9%, p = 0.02). The survival in the PFH group was marginally lower than the NFH group, a difference found to be attributable to the higher prevalence of extrapancreatic malignancies. Conclusion: Characteristics of surgically resected IPMNs are not different between patients with and without a family history of pancreatic cancer. Most importantly, the incidence of invasive disease is not different, suggesting that these lesions may not be more aggressive when they occur in the presence of a family history of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)358-363
Number of pages6
JournalPancreatology
Volume12
Issue number4
DOIs
StatePublished - Jan 1 2012

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Pancreatic Neoplasms
Neoplasms
General Hospitals
Adenocarcinoma
Demography
Survival
Incidence

Keywords

  • Family history
  • Intraductal papillary mucinous neoplasm
  • Pancreatic cancer

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

Cite this

Nehra, D., Oyarvide, V. M., Mino-Kenudson, M., Thayer, S. P., Ferrone, C. R., Wargo, J. A., ... Castillo, C. F. D. (2012). Intraductal papillary mucinous neoplasms: Does a family history of pancreatic cancer matter? Pancreatology, 12(4), 358-363. https://doi.org/10.1016/j.pan.2012.05.011

Intraductal papillary mucinous neoplasms : Does a family history of pancreatic cancer matter? / Nehra, Deepika; Oyarvide, Vicente Morales; Mino-Kenudson, Mari; Thayer, Sarah P.; Ferrone, Cristina R.; Wargo, Jennifer A.; Muzikansky, Alona; Finkelstein, Dianne; Warshawa, Andrew L.; Castillo, Carlos Fernández Del.

In: Pancreatology, Vol. 12, No. 4, 01.01.2012, p. 358-363.

Research output: Contribution to journalArticle

Nehra, D, Oyarvide, VM, Mino-Kenudson, M, Thayer, SP, Ferrone, CR, Wargo, JA, Muzikansky, A, Finkelstein, D, Warshawa, AL & Castillo, CFD 2012, 'Intraductal papillary mucinous neoplasms: Does a family history of pancreatic cancer matter?', Pancreatology, vol. 12, no. 4, pp. 358-363. https://doi.org/10.1016/j.pan.2012.05.011
Nehra, Deepika ; Oyarvide, Vicente Morales ; Mino-Kenudson, Mari ; Thayer, Sarah P. ; Ferrone, Cristina R. ; Wargo, Jennifer A. ; Muzikansky, Alona ; Finkelstein, Dianne ; Warshawa, Andrew L. ; Castillo, Carlos Fernández Del. / Intraductal papillary mucinous neoplasms : Does a family history of pancreatic cancer matter?. In: Pancreatology. 2012 ; Vol. 12, No. 4. pp. 358-363.
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abstract = "Background/Objectives: The purpose of this study is to compare surgically resected intraductal papillary mucinous neoplasms (IPMNs) in patients with and without a family history of pancreatic cancer to gain insight into differences that may suggest the need for differential management. Methods: A retrospective review of patients who underwent resection of an IPMN at the Massachusetts General Hospital (1990e2011) was conducted. Three hundred and twenty-four patients of whom 45 (13.9{\%}) had a family history of pancreatic cancer were identified. Patients with (PFH) and without (NFH) a family history of pancreatic cancer were compared. Results: There were no differences in demographic characteristics between groups. Extra-pancreatic malignancies diagnosed prior to the IPMN were more common in those with a PFH (35.6{\%} vs 20.1{\%}, p = 0.03). There were no differences in IPMN characteristics between groups including no difference in the presence of invasive disease (p = 0.55). Concurrent pancreatic ductal adenocarcinomas were more common in those with a PFH (11.1{\%} vs 2.9{\%}, p = 0.02). The survival in the PFH group was marginally lower than the NFH group, a difference found to be attributable to the higher prevalence of extrapancreatic malignancies. Conclusion: Characteristics of surgically resected IPMNs are not different between patients with and without a family history of pancreatic cancer. Most importantly, the incidence of invasive disease is not different, suggesting that these lesions may not be more aggressive when they occur in the presence of a family history of pancreatic cancer.",
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AU - Nehra, Deepika

AU - Oyarvide, Vicente Morales

AU - Mino-Kenudson, Mari

AU - Thayer, Sarah P.

AU - Ferrone, Cristina R.

AU - Wargo, Jennifer A.

AU - Muzikansky, Alona

AU - Finkelstein, Dianne

AU - Warshawa, Andrew L.

AU - Castillo, Carlos Fernández Del

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N2 - Background/Objectives: The purpose of this study is to compare surgically resected intraductal papillary mucinous neoplasms (IPMNs) in patients with and without a family history of pancreatic cancer to gain insight into differences that may suggest the need for differential management. Methods: A retrospective review of patients who underwent resection of an IPMN at the Massachusetts General Hospital (1990e2011) was conducted. Three hundred and twenty-four patients of whom 45 (13.9%) had a family history of pancreatic cancer were identified. Patients with (PFH) and without (NFH) a family history of pancreatic cancer were compared. Results: There were no differences in demographic characteristics between groups. Extra-pancreatic malignancies diagnosed prior to the IPMN were more common in those with a PFH (35.6% vs 20.1%, p = 0.03). There were no differences in IPMN characteristics between groups including no difference in the presence of invasive disease (p = 0.55). Concurrent pancreatic ductal adenocarcinomas were more common in those with a PFH (11.1% vs 2.9%, p = 0.02). The survival in the PFH group was marginally lower than the NFH group, a difference found to be attributable to the higher prevalence of extrapancreatic malignancies. Conclusion: Characteristics of surgically resected IPMNs are not different between patients with and without a family history of pancreatic cancer. Most importantly, the incidence of invasive disease is not different, suggesting that these lesions may not be more aggressive when they occur in the presence of a family history of pancreatic cancer.

AB - Background/Objectives: The purpose of this study is to compare surgically resected intraductal papillary mucinous neoplasms (IPMNs) in patients with and without a family history of pancreatic cancer to gain insight into differences that may suggest the need for differential management. Methods: A retrospective review of patients who underwent resection of an IPMN at the Massachusetts General Hospital (1990e2011) was conducted. Three hundred and twenty-four patients of whom 45 (13.9%) had a family history of pancreatic cancer were identified. Patients with (PFH) and without (NFH) a family history of pancreatic cancer were compared. Results: There were no differences in demographic characteristics between groups. Extra-pancreatic malignancies diagnosed prior to the IPMN were more common in those with a PFH (35.6% vs 20.1%, p = 0.03). There were no differences in IPMN characteristics between groups including no difference in the presence of invasive disease (p = 0.55). Concurrent pancreatic ductal adenocarcinomas were more common in those with a PFH (11.1% vs 2.9%, p = 0.02). The survival in the PFH group was marginally lower than the NFH group, a difference found to be attributable to the higher prevalence of extrapancreatic malignancies. Conclusion: Characteristics of surgically resected IPMNs are not different between patients with and without a family history of pancreatic cancer. Most importantly, the incidence of invasive disease is not different, suggesting that these lesions may not be more aggressive when they occur in the presence of a family history of pancreatic cancer.

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KW - Pancreatic cancer

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