Intracranial pressure influences the behavior of the optic nerve head

Yi Hua, Junfei Tong, Deepta A Ghate, Sachin Kedar, Linxia Gu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In this work, the biomechanical responses of the optic nerve head (ONH) to acute elevations in intracranial pressure (ICP) were systematically investigated through numerical modeling. An orthogonal experimental design was developed to quantify the influence of ten input factors that govern the anatomy and material properties of the ONH on the peak maximum principal strain (MPS) in the lamina cribrosa (LC) and postlaminar neural tissue (PLNT). Results showed that the sensitivity of ONH responses to various input factors was region-specific. In the LC, the peak MPS was most strongly dependent on the sclera thickness, LC modulus, and scleral canal size, whereas in the PLNT, the peak MPS was more sensitive to the scleral canal size, neural tissue modulus, and pia mater modulus. The enforcement of clinically relevant ICP in the retro-orbital subarachnoid space influenced the sensitivity analysis. It also induced much larger strains in the PLNT than in the LC. Moreover, acute elevation of ICP leads to dramatic strain distribution changes in the PLNT, but had minimal impact on the LC. This work could help to better understand patient-specific responses, to provide guidance on biomechanical factors resulting in optic nerve diseases, such as glaucoma, papilledema, and ischemic optic neuropathy, and to illuminate the possibilities for exploiting their potential to treat and prevent ONH diseases.

Original languageEnglish (US)
Article number031003
JournalJournal of Biomechanical Engineering
Volume139
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Optic Disk
Intracranial Pressure
Optics
Tissue
Optic Nerve Diseases
Intracranial Hypertension
Canals
Pia Mater
Ischemic Optic Neuropathy
Papilledema
Subarachnoid Space
Sclera
Neural Tube
Glaucoma
Anatomy
Research Design
Design of experiments
Sensitivity analysis
Materials properties

Keywords

  • Biomechanics
  • Glaucoma
  • Intracranial pressure
  • Lamina cribrosa
  • Optic nerve head
  • Postlaminar neural tissue

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

Cite this

Intracranial pressure influences the behavior of the optic nerve head. / Hua, Yi; Tong, Junfei; Ghate, Deepta A; Kedar, Sachin; Gu, Linxia.

In: Journal of Biomechanical Engineering, Vol. 139, No. 3, 031003, 01.03.2017.

Research output: Contribution to journalArticle

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