Intracoronary epinephrine attenuates baroreflex control of heart rate in the conscious dog

M. J. Holmberg, A. J. Gorman, K. G. Cornish, Irving H Zucker

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the present study, the reflex effects of low-dose (12.5-50 ng·kg-1·min-1) intracoronary epinephrine infusion on the arterial baroreflex control of heart rate were studied. Mean arterial blood pressure-heart rate curves were constructed by changing mean arterial blood pressure with graded occlusions of the descending aorta and inferior vena cava. Intracoronary epinephrine increased left ventricular dP/dt(max) by an average of 309 ± 67.0 mmHg/s but did not alter resting mean arterial blood pressure or heart rate. Peak sensitivity, the maximum absolute slope along the mean arterial blood pressure-heart rate curve, and heart rate range were 32.7 ± 3.2 and 26.7 ± 2.5% less during intracoronary epinephrine compared with control, respectively. Intracoronary epinephrine did not alter the median, threshold, or saturation pressure of the mean arterial blood pressure-heart rate curve. Lidocaine block of the pericoronary nerves, which blocked the ventricular afferent pathway, eliminated the effects of intracoronary epinephrine on the arterial baroreflex. Atropine abolished the effects of intracoronary epinephrine on arterial baroreflex control of heart rate. We conclude that intracoronary epinephrine reflexly attenuates the arterial baroreflex control of heart rate in the conscious dog through activation of ventricular receptors. This response is mediated by cardiac parasympathetic efferents common to both reflex arcs.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume16
Issue number2
StatePublished - Jan 1 1984

Fingerprint

Baroreflex
Epinephrine
Arterial Pressure
Heart Rate
Dogs
Reflex
Afferent Pathways
Nerve Block
Inferior Vena Cava
Lidocaine
Thoracic Aorta
Atropine
Pressure

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Intracoronary epinephrine attenuates baroreflex control of heart rate in the conscious dog. / Holmberg, M. J.; Gorman, A. J.; Cornish, K. G.; Zucker, Irving H.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 16, No. 2, 01.01.1984.

Research output: Contribution to journalArticle

@article{abc084615bf64d26b9a298f78f30b119,
title = "Intracoronary epinephrine attenuates baroreflex control of heart rate in the conscious dog",
abstract = "In the present study, the reflex effects of low-dose (12.5-50 ng·kg-1·min-1) intracoronary epinephrine infusion on the arterial baroreflex control of heart rate were studied. Mean arterial blood pressure-heart rate curves were constructed by changing mean arterial blood pressure with graded occlusions of the descending aorta and inferior vena cava. Intracoronary epinephrine increased left ventricular dP/dt(max) by an average of 309 ± 67.0 mmHg/s but did not alter resting mean arterial blood pressure or heart rate. Peak sensitivity, the maximum absolute slope along the mean arterial blood pressure-heart rate curve, and heart rate range were 32.7 ± 3.2 and 26.7 ± 2.5{\%} less during intracoronary epinephrine compared with control, respectively. Intracoronary epinephrine did not alter the median, threshold, or saturation pressure of the mean arterial blood pressure-heart rate curve. Lidocaine block of the pericoronary nerves, which blocked the ventricular afferent pathway, eliminated the effects of intracoronary epinephrine on the arterial baroreflex. Atropine abolished the effects of intracoronary epinephrine on arterial baroreflex control of heart rate. We conclude that intracoronary epinephrine reflexly attenuates the arterial baroreflex control of heart rate in the conscious dog through activation of ventricular receptors. This response is mediated by cardiac parasympathetic efferents common to both reflex arcs.",
author = "Holmberg, {M. J.} and Gorman, {A. J.} and Cornish, {K. G.} and Zucker, {Irving H}",
year = "1984",
month = "1",
day = "1",
language = "English (US)",
volume = "16",
journal = "American Journal of Physiology - Renal Physiology",
issn = "0363-6127",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - Intracoronary epinephrine attenuates baroreflex control of heart rate in the conscious dog

AU - Holmberg, M. J.

AU - Gorman, A. J.

AU - Cornish, K. G.

AU - Zucker, Irving H

PY - 1984/1/1

Y1 - 1984/1/1

N2 - In the present study, the reflex effects of low-dose (12.5-50 ng·kg-1·min-1) intracoronary epinephrine infusion on the arterial baroreflex control of heart rate were studied. Mean arterial blood pressure-heart rate curves were constructed by changing mean arterial blood pressure with graded occlusions of the descending aorta and inferior vena cava. Intracoronary epinephrine increased left ventricular dP/dt(max) by an average of 309 ± 67.0 mmHg/s but did not alter resting mean arterial blood pressure or heart rate. Peak sensitivity, the maximum absolute slope along the mean arterial blood pressure-heart rate curve, and heart rate range were 32.7 ± 3.2 and 26.7 ± 2.5% less during intracoronary epinephrine compared with control, respectively. Intracoronary epinephrine did not alter the median, threshold, or saturation pressure of the mean arterial blood pressure-heart rate curve. Lidocaine block of the pericoronary nerves, which blocked the ventricular afferent pathway, eliminated the effects of intracoronary epinephrine on the arterial baroreflex. Atropine abolished the effects of intracoronary epinephrine on arterial baroreflex control of heart rate. We conclude that intracoronary epinephrine reflexly attenuates the arterial baroreflex control of heart rate in the conscious dog through activation of ventricular receptors. This response is mediated by cardiac parasympathetic efferents common to both reflex arcs.

AB - In the present study, the reflex effects of low-dose (12.5-50 ng·kg-1·min-1) intracoronary epinephrine infusion on the arterial baroreflex control of heart rate were studied. Mean arterial blood pressure-heart rate curves were constructed by changing mean arterial blood pressure with graded occlusions of the descending aorta and inferior vena cava. Intracoronary epinephrine increased left ventricular dP/dt(max) by an average of 309 ± 67.0 mmHg/s but did not alter resting mean arterial blood pressure or heart rate. Peak sensitivity, the maximum absolute slope along the mean arterial blood pressure-heart rate curve, and heart rate range were 32.7 ± 3.2 and 26.7 ± 2.5% less during intracoronary epinephrine compared with control, respectively. Intracoronary epinephrine did not alter the median, threshold, or saturation pressure of the mean arterial blood pressure-heart rate curve. Lidocaine block of the pericoronary nerves, which blocked the ventricular afferent pathway, eliminated the effects of intracoronary epinephrine on the arterial baroreflex. Atropine abolished the effects of intracoronary epinephrine on arterial baroreflex control of heart rate. We conclude that intracoronary epinephrine reflexly attenuates the arterial baroreflex control of heart rate in the conscious dog through activation of ventricular receptors. This response is mediated by cardiac parasympathetic efferents common to both reflex arcs.

UR - http://www.scopus.com/inward/record.url?scp=0021471484&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021471484&partnerID=8YFLogxK

M3 - Article

VL - 16

JO - American Journal of Physiology - Renal Physiology

JF - American Journal of Physiology - Renal Physiology

SN - 0363-6127

IS - 2

ER -