Intracellular degradation of newly synthesized collagen

S. I. Rennard, L. E. Stier, R. G. Crystal

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The intracellular degradation of newly synthesized collagen is a cellular pathway that accounts for the destruction of 10-60% of collagen synthesized by a variety of cell types prior to secretion. This pathway can serve in a regulatory role to limit the secretion of defective molecules, and, in response to some extracellular mediators, regulates the amount and type of collagens secreted. In addition, this pathway may contribute to the pathogenesis of a variety of conditions affecting the extracellular matrix including fibrosis, diabetes mellitus, and scurvy.

Original languageEnglish (US)
Pages (from-to)77-82
Number of pages6
JournalJournal of Investigative Dermatology
Volume79
Issue numberSuppl. 1
DOIs
StatePublished - Jan 1 1982

Fingerprint

Collagen
Degradation
Scurvy
Medical problems
Extracellular Matrix
Diabetes Mellitus
Fibrosis
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Intracellular degradation of newly synthesized collagen. / Rennard, S. I.; Stier, L. E.; Crystal, R. G.

In: Journal of Investigative Dermatology, Vol. 79, No. Suppl. 1, 01.01.1982, p. 77-82.

Research output: Contribution to journalArticle

Rennard, S. I. ; Stier, L. E. ; Crystal, R. G. / Intracellular degradation of newly synthesized collagen. In: Journal of Investigative Dermatology. 1982 ; Vol. 79, No. Suppl. 1. pp. 77-82.
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