Intestinal neoplasia in the Apc(Min) mouse: Independence from the microbial and natural killer (beige locus) status

William F. Dove, Linda Clipson, Karen A. Gould, Cindy Luongo, David J. Marshall, Amy R. Moser, Michael A. Newton, Russell F. Jacoby

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

We have tested the hypothesis that enteric bacteria are necessary for formation of intestinal adenomas in C57BL/6-Apc(Min)/+ mouse. Germ-free mice developed 2-fold fewer adenomas than conventional controls in the medial small intestine (7.3 versus 14.9; P < 0.003), but there were no significant differences in the rest of the intestinal tract. We conclude that microbial status does not strongly alter the adenoma phenotype in this mouse model of familial adenomatous polyposis. In parallel, we have found that C57BL/6- Apc(MIN)/+ mice mutated at the beige locus, which controls natural killer activity, are also unaltered in adenoma multiplicity.

Original languageEnglish (US)
Pages (from-to)812-814
Number of pages3
JournalCancer Research
Volume57
Issue number5
StatePublished - Jan 1 1997

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Adenoma
Neoplasms
Adenomatous Polyposis Coli
Internal-External Control
Enterobacteriaceae
Small Intestine
Phenotype

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Dove, W. F., Clipson, L., Gould, K. A., Luongo, C., Marshall, D. J., Moser, A. R., ... Jacoby, R. F. (1997). Intestinal neoplasia in the Apc(Min) mouse: Independence from the microbial and natural killer (beige locus) status. Cancer Research, 57(5), 812-814.

Intestinal neoplasia in the Apc(Min) mouse : Independence from the microbial and natural killer (beige locus) status. / Dove, William F.; Clipson, Linda; Gould, Karen A.; Luongo, Cindy; Marshall, David J.; Moser, Amy R.; Newton, Michael A.; Jacoby, Russell F.

In: Cancer Research, Vol. 57, No. 5, 01.01.1997, p. 812-814.

Research output: Contribution to journalArticle

Dove, WF, Clipson, L, Gould, KA, Luongo, C, Marshall, DJ, Moser, AR, Newton, MA & Jacoby, RF 1997, 'Intestinal neoplasia in the Apc(Min) mouse: Independence from the microbial and natural killer (beige locus) status', Cancer Research, vol. 57, no. 5, pp. 812-814.
Dove, William F. ; Clipson, Linda ; Gould, Karen A. ; Luongo, Cindy ; Marshall, David J. ; Moser, Amy R. ; Newton, Michael A. ; Jacoby, Russell F. / Intestinal neoplasia in the Apc(Min) mouse : Independence from the microbial and natural killer (beige locus) status. In: Cancer Research. 1997 ; Vol. 57, No. 5. pp. 812-814.
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