Interstitial Lung Diseases of Unknown Cause: Disorders Characterized by Chronic Inflammation of the Lower Respiratory Tract

Ronald G. Crystal, Peter B. Bitterman, Stephen I. Rennard, Allan J. Hance, Brendan A. Keogh

Research output: Contribution to journalReview article

211 Scopus citations


Sarcoidosis Sarcoidosis is a multisystem granulomatous disease of unknown cause characterized by enhanced cellular immune processes at sites of involvement.36,53,59,152 Almost all organs can be affected by the disease, but the lower respiratory tract is the site most commonly associated with morbidity and mortality.152 At least 90 per cent of patients with sarcoidosis have pulmonary manifestations; 20 to 25 per cent of these patients have a permanent loss of lung function, and 5 to 10 per cent die from complications of the disease.153,154 Sarcoidosis is found throughout the world.152 153 154 155 In the industrialized nations, the prevalence varies by sex, geographic location.

Original languageEnglish (US)
Pages (from-to)235-244
Number of pages10
JournalNew England Journal of Medicine
Issue number4
Publication statusPublished - Jan 26 1984


ASJC Scopus subject areas

  • Medicine(all)

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