Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders

Yu Cai, Jyothi Arikkath, Lu Yang, Minglei Guo, Palsamy Periyasamy, Shilpa J Buch

Research output: Contribution to journalReview article

74 Citations (Scopus)

Abstract

The common underlying feature of most neurodegenerative diseases such as Alzheimer disease (AD), prion diseases, Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) involves accumulation of misfolded proteins leading to initiation of endoplasmic reticulum (ER) stress and stimulation of the unfolded protein response (UPR). Additionally, ER stress more recently has been implicated in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Autophagy plays an essential role in the clearance of aggregated toxic proteins and degradation of the damaged organelles. There is evidence that autophagy ameliorates ER stress by eliminating accumulated misfolded proteins. Both abnormal UPR and impaired autophagy have been implicated as a causative mechanism in the development of various neurodegenerative diseases. This review highlights recent advances in the field on the role of ER stress and autophagy in AD, prion diseases, PD, ALS and HAND with the involvement of key signaling pathways in these processes and implications for future development of therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)225-244
Number of pages20
JournalAutophagy
Volume12
Issue number2
DOIs
StatePublished - Jan 1 2016

Fingerprint

Endoplasmic Reticulum Stress
Autophagy
Neurodegenerative Diseases
Unfolded Protein Response
Prion Diseases
Amyotrophic Lateral Sclerosis
Parkinson Disease
Alzheimer Disease
HIV
Poisons
Organelles
Proteolysis
Proteins
Neurocognitive Disorders
Therapeutics

Keywords

  • Alzheimer disease
  • Amyotrophic lateral sclerosis and HIV-associated neurocognitive disorders
  • Autophagy
  • ER stress
  • Neurodegenerative disorders
  • Parkinson disease
  • Prion diseases

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders. / Cai, Yu; Arikkath, Jyothi; Yang, Lu; Guo, Minglei; Periyasamy, Palsamy; Buch, Shilpa J.

In: Autophagy, Vol. 12, No. 2, 01.01.2016, p. 225-244.

Research output: Contribution to journalReview article

@article{2aeffbf6964a4421ae1d0109dd662992,
title = "Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders",
abstract = "The common underlying feature of most neurodegenerative diseases such as Alzheimer disease (AD), prion diseases, Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) involves accumulation of misfolded proteins leading to initiation of endoplasmic reticulum (ER) stress and stimulation of the unfolded protein response (UPR). Additionally, ER stress more recently has been implicated in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Autophagy plays an essential role in the clearance of aggregated toxic proteins and degradation of the damaged organelles. There is evidence that autophagy ameliorates ER stress by eliminating accumulated misfolded proteins. Both abnormal UPR and impaired autophagy have been implicated as a causative mechanism in the development of various neurodegenerative diseases. This review highlights recent advances in the field on the role of ER stress and autophagy in AD, prion diseases, PD, ALS and HAND with the involvement of key signaling pathways in these processes and implications for future development of therapeutic strategies.",
keywords = "Alzheimer disease, Amyotrophic lateral sclerosis and HIV-associated neurocognitive disorders, Autophagy, ER stress, Neurodegenerative disorders, Parkinson disease, Prion diseases",
author = "Yu Cai and Jyothi Arikkath and Lu Yang and Minglei Guo and Palsamy Periyasamy and Buch, {Shilpa J}",
year = "2016",
month = "1",
day = "1",
doi = "10.1080/15548627.2015.1121360",
language = "English (US)",
volume = "12",
pages = "225--244",
journal = "Autophagy",
issn = "1554-8627",
publisher = "Landes Bioscience",
number = "2",

}

TY - JOUR

T1 - Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders

AU - Cai, Yu

AU - Arikkath, Jyothi

AU - Yang, Lu

AU - Guo, Minglei

AU - Periyasamy, Palsamy

AU - Buch, Shilpa J

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The common underlying feature of most neurodegenerative diseases such as Alzheimer disease (AD), prion diseases, Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) involves accumulation of misfolded proteins leading to initiation of endoplasmic reticulum (ER) stress and stimulation of the unfolded protein response (UPR). Additionally, ER stress more recently has been implicated in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Autophagy plays an essential role in the clearance of aggregated toxic proteins and degradation of the damaged organelles. There is evidence that autophagy ameliorates ER stress by eliminating accumulated misfolded proteins. Both abnormal UPR and impaired autophagy have been implicated as a causative mechanism in the development of various neurodegenerative diseases. This review highlights recent advances in the field on the role of ER stress and autophagy in AD, prion diseases, PD, ALS and HAND with the involvement of key signaling pathways in these processes and implications for future development of therapeutic strategies.

AB - The common underlying feature of most neurodegenerative diseases such as Alzheimer disease (AD), prion diseases, Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) involves accumulation of misfolded proteins leading to initiation of endoplasmic reticulum (ER) stress and stimulation of the unfolded protein response (UPR). Additionally, ER stress more recently has been implicated in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Autophagy plays an essential role in the clearance of aggregated toxic proteins and degradation of the damaged organelles. There is evidence that autophagy ameliorates ER stress by eliminating accumulated misfolded proteins. Both abnormal UPR and impaired autophagy have been implicated as a causative mechanism in the development of various neurodegenerative diseases. This review highlights recent advances in the field on the role of ER stress and autophagy in AD, prion diseases, PD, ALS and HAND with the involvement of key signaling pathways in these processes and implications for future development of therapeutic strategies.

KW - Alzheimer disease

KW - Amyotrophic lateral sclerosis and HIV-associated neurocognitive disorders

KW - Autophagy

KW - ER stress

KW - Neurodegenerative disorders

KW - Parkinson disease

KW - Prion diseases

UR - http://www.scopus.com/inward/record.url?scp=84964501883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964501883&partnerID=8YFLogxK

U2 - 10.1080/15548627.2015.1121360

DO - 10.1080/15548627.2015.1121360

M3 - Review article

C2 - 26902584

AN - SCOPUS:84964501883

VL - 12

SP - 225

EP - 244

JO - Autophagy

JF - Autophagy

SN - 1554-8627

IS - 2

ER -