Intermediate lymphocytic lymphoma: Immunophenotypic and cytogenetic findings

D. D. Weisenburger, W. G. Sanger, James Olen Armitage, D. T. Purtilo

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

A detailed immunohistologic and cytogenetic analysis of 12 cases of intermediate lymphocytic lymphoma was performed. The characteristic immunophenotype of intermediate lymphocytic lymphoma was: surface IgM and IgD+, BA1+, B1+, BA2-, B2-, B4+, Leu 14+, Leu 1+, HLA-DR+, and common acute lymphocytic leukemia associated (CALLA) antigen negative. Clonal chromosome abnormalities were identified in ten cases, with structural or numerical abnormalities of chromosomes 11 or 12 in nine cases. Five cases had structural abnormalities involving the long arm of chromosome 11; three of these had translocations with chromosome 14 at band q32. Three cases had trisomy 12, and one case had a translocation involving the long arm of chromosome 12. The tenth case had a translocation involving the long arms of chromosomes 7 and 9. These characteristic immunophenotypic and cytogenetic findings suggest a close lineage relationship between intermediate lymphocytic lymphoma and small lymphocytic (well differentiated) lymphoma/chronic lymphocytic leukemia. Their differing clinical, cytologic, and architectural features suggest, however, that intermediate lymphocytic lymphoma should be considered a separate category of lymphocytic lymphoma in the International Working Formulation.

Original languageEnglish (US)
Pages (from-to)1617-1621
Number of pages5
JournalBlood
Volume69
Issue number6
StatePublished - Jan 1 1987

Fingerprint

Mantle-Cell Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Chromosomes
Cytogenetics
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 14
Immunoglobulin D
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 7
Cytogenetic Analysis
Trisomy
HLA-DR Antigens
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chromosome Aberrations
Immunoglobulin M
Antigens

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Weisenburger, D. D., Sanger, W. G., Armitage, J. O., & Purtilo, D. T. (1987). Intermediate lymphocytic lymphoma: Immunophenotypic and cytogenetic findings. Blood, 69(6), 1617-1621.

Intermediate lymphocytic lymphoma : Immunophenotypic and cytogenetic findings. / Weisenburger, D. D.; Sanger, W. G.; Armitage, James Olen; Purtilo, D. T.

In: Blood, Vol. 69, No. 6, 01.01.1987, p. 1617-1621.

Research output: Contribution to journalArticle

Weisenburger, DD, Sanger, WG, Armitage, JO & Purtilo, DT 1987, 'Intermediate lymphocytic lymphoma: Immunophenotypic and cytogenetic findings', Blood, vol. 69, no. 6, pp. 1617-1621.
Weisenburger DD, Sanger WG, Armitage JO, Purtilo DT. Intermediate lymphocytic lymphoma: Immunophenotypic and cytogenetic findings. Blood. 1987 Jan 1;69(6):1617-1621.
Weisenburger, D. D. ; Sanger, W. G. ; Armitage, James Olen ; Purtilo, D. T. / Intermediate lymphocytic lymphoma : Immunophenotypic and cytogenetic findings. In: Blood. 1987 ; Vol. 69, No. 6. pp. 1617-1621.
@article{4b8b42cfe3794dd7b5c7d9e2f753ecd1,
title = "Intermediate lymphocytic lymphoma: Immunophenotypic and cytogenetic findings",
abstract = "A detailed immunohistologic and cytogenetic analysis of 12 cases of intermediate lymphocytic lymphoma was performed. The characteristic immunophenotype of intermediate lymphocytic lymphoma was: surface IgM and IgD+, BA1+, B1+, BA2-, B2-, B4+, Leu 14+, Leu 1+, HLA-DR+, and common acute lymphocytic leukemia associated (CALLA) antigen negative. Clonal chromosome abnormalities were identified in ten cases, with structural or numerical abnormalities of chromosomes 11 or 12 in nine cases. Five cases had structural abnormalities involving the long arm of chromosome 11; three of these had translocations with chromosome 14 at band q32. Three cases had trisomy 12, and one case had a translocation involving the long arm of chromosome 12. The tenth case had a translocation involving the long arms of chromosomes 7 and 9. These characteristic immunophenotypic and cytogenetic findings suggest a close lineage relationship between intermediate lymphocytic lymphoma and small lymphocytic (well differentiated) lymphoma/chronic lymphocytic leukemia. Their differing clinical, cytologic, and architectural features suggest, however, that intermediate lymphocytic lymphoma should be considered a separate category of lymphocytic lymphoma in the International Working Formulation.",
author = "Weisenburger, {D. D.} and Sanger, {W. G.} and Armitage, {James Olen} and Purtilo, {D. T.}",
year = "1987",
month = "1",
day = "1",
language = "English (US)",
volume = "69",
pages = "1617--1621",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "6",

}

TY - JOUR

T1 - Intermediate lymphocytic lymphoma

T2 - Immunophenotypic and cytogenetic findings

AU - Weisenburger, D. D.

AU - Sanger, W. G.

AU - Armitage, James Olen

AU - Purtilo, D. T.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - A detailed immunohistologic and cytogenetic analysis of 12 cases of intermediate lymphocytic lymphoma was performed. The characteristic immunophenotype of intermediate lymphocytic lymphoma was: surface IgM and IgD+, BA1+, B1+, BA2-, B2-, B4+, Leu 14+, Leu 1+, HLA-DR+, and common acute lymphocytic leukemia associated (CALLA) antigen negative. Clonal chromosome abnormalities were identified in ten cases, with structural or numerical abnormalities of chromosomes 11 or 12 in nine cases. Five cases had structural abnormalities involving the long arm of chromosome 11; three of these had translocations with chromosome 14 at band q32. Three cases had trisomy 12, and one case had a translocation involving the long arm of chromosome 12. The tenth case had a translocation involving the long arms of chromosomes 7 and 9. These characteristic immunophenotypic and cytogenetic findings suggest a close lineage relationship between intermediate lymphocytic lymphoma and small lymphocytic (well differentiated) lymphoma/chronic lymphocytic leukemia. Their differing clinical, cytologic, and architectural features suggest, however, that intermediate lymphocytic lymphoma should be considered a separate category of lymphocytic lymphoma in the International Working Formulation.

AB - A detailed immunohistologic and cytogenetic analysis of 12 cases of intermediate lymphocytic lymphoma was performed. The characteristic immunophenotype of intermediate lymphocytic lymphoma was: surface IgM and IgD+, BA1+, B1+, BA2-, B2-, B4+, Leu 14+, Leu 1+, HLA-DR+, and common acute lymphocytic leukemia associated (CALLA) antigen negative. Clonal chromosome abnormalities were identified in ten cases, with structural or numerical abnormalities of chromosomes 11 or 12 in nine cases. Five cases had structural abnormalities involving the long arm of chromosome 11; three of these had translocations with chromosome 14 at band q32. Three cases had trisomy 12, and one case had a translocation involving the long arm of chromosome 12. The tenth case had a translocation involving the long arms of chromosomes 7 and 9. These characteristic immunophenotypic and cytogenetic findings suggest a close lineage relationship between intermediate lymphocytic lymphoma and small lymphocytic (well differentiated) lymphoma/chronic lymphocytic leukemia. Their differing clinical, cytologic, and architectural features suggest, however, that intermediate lymphocytic lymphoma should be considered a separate category of lymphocytic lymphoma in the International Working Formulation.

UR - http://www.scopus.com/inward/record.url?scp=0023187607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023187607&partnerID=8YFLogxK

M3 - Article

C2 - 3555648

AN - SCOPUS:0023187607

VL - 69

SP - 1617

EP - 1621

JO - Blood

JF - Blood

SN - 0006-4971

IS - 6

ER -