Interleukin-2 receptor-inducing factor(S) in adult T cell leukemia

Junji Yodoi, Yutaka Tagaya, Masafumi Okada, Yoshihisa Taniguchi, Masakazu Hirata, Mayumi Naramura, Michiyuki Maeda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The expression of the interleukin-2 receptor (IL-2-R) is regulated by transcriptional and post-transcriptional mechanisms. IL-2-R gene expression is induced by pharmacological agents including calcium ions, phorbol esters such as phorbol myristate acetate (PMA) and forskolin (FK), a direct activator of adenylate cyclase. HTLV-I(+) leukemic T cells and T cell lines from patients with adult T cell leukemia (ATL) continuously expressed IL-2-R without production of IL-2. However, there was no abnormality of the structural gene for IL-2- R in these cell lines as well as in fresh leukemiccells of ATL. We have detected that many HTLV-I(+) T4(+) T cell lines constitutively produce a non-IL-2 lymphokine named ATL-derived factor (ADF), which inducedthe expression of the high-affinity IL-2-R on a variety of cells including HTLV-I(+) T cells, myeloid leukemia cells and YT cells. IL-2-R-inducing agents such as ADF and FK were shown to induce elevation of the mRNA levels for IL-2-R through transcriptional enhancement of the IL-2-R gene. The possible involvement of IL-2-R- inducing cytokines in the physiological lymphocyte activation and the leukemogenesis in ATL and other T cell leukemias is discussed.

Original languageEnglish (US)
Pages (from-to)56-63
Number of pages8
JournalActa Haematologica
Volume78
DOIs
StatePublished - Jan 1 1987

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Adult T Cell Leukemia Lymphoma
Interleukin-2 Receptors
Human T-lymphotropic virus 1
T-Cell Leukemia
Colforsin
T-Lymphocytes
Cell Line
Interleukin-2
CD4-Positive T-Lymphocytes
Myeloid Leukemia
Lymphokines
Phorbol Esters
Tetradecanoylphorbol Acetate
Myeloid Cells
Lymphocyte Activation
Adenylyl Cyclases
Genes
Pharmacology
Ions
Cytokines

Keywords

  • Adult T cell leukemia
  • Adult T cell leukemia-derived factor
  • HTLV-1
  • Interleukin-2-receptor

ASJC Scopus subject areas

  • Hematology

Cite this

Yodoi, J., Tagaya, Y., Okada, M., Taniguchi, Y., Hirata, M., Naramura, M., & Maeda, M. (1987). Interleukin-2 receptor-inducing factor(S) in adult T cell leukemia. Acta Haematologica, 78, 56-63. https://doi.org/10.1159/000205904

Interleukin-2 receptor-inducing factor(S) in adult T cell leukemia. / Yodoi, Junji; Tagaya, Yutaka; Okada, Masafumi; Taniguchi, Yoshihisa; Hirata, Masakazu; Naramura, Mayumi; Maeda, Michiyuki.

In: Acta Haematologica, Vol. 78, 01.01.1987, p. 56-63.

Research output: Contribution to journalArticle

Yodoi, J, Tagaya, Y, Okada, M, Taniguchi, Y, Hirata, M, Naramura, M & Maeda, M 1987, 'Interleukin-2 receptor-inducing factor(S) in adult T cell leukemia', Acta Haematologica, vol. 78, pp. 56-63. https://doi.org/10.1159/000205904
Yodoi J, Tagaya Y, Okada M, Taniguchi Y, Hirata M, Naramura M et al. Interleukin-2 receptor-inducing factor(S) in adult T cell leukemia. Acta Haematologica. 1987 Jan 1;78:56-63. https://doi.org/10.1159/000205904
Yodoi, Junji ; Tagaya, Yutaka ; Okada, Masafumi ; Taniguchi, Yoshihisa ; Hirata, Masakazu ; Naramura, Mayumi ; Maeda, Michiyuki. / Interleukin-2 receptor-inducing factor(S) in adult T cell leukemia. In: Acta Haematologica. 1987 ; Vol. 78. pp. 56-63.
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