Abstract

Neural fibrosis in leprosy, the disease caused by the obligate intracellular bacterium, Mycobacterium leprae, is closely related to the cell-mediated immune response to this microorganism. The fibrosis appears to be due to soluble mediators released by the immune effector cells. Interleukin 1, a macrophage product that stimulates fibroblast migration, proliferation and synthetic activity, possesses the requisite properties to qualify for such a mediator.

Original languageEnglish (US)
Pages (from-to)143-150
Number of pages8
JournalMedical Hypotheses
Volume20
Issue number2
DOIs
StatePublished - Jun 1986

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Leprosy
Interleukin-1
Fibrosis
Mycobacterium leprae
Fibroblasts
Macrophages
Bacteria

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Interleukin 1 - A possible mediator of neural fibrosis in leprosy. / Band, Hamid.

In: Medical Hypotheses, Vol. 20, No. 2, 06.1986, p. 143-150.

Research output: Contribution to journalArticle

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abstract = "Neural fibrosis in leprosy, the disease caused by the obligate intracellular bacterium, Mycobacterium leprae, is closely related to the cell-mediated immune response to this microorganism. The fibrosis appears to be due to soluble mediators released by the immune effector cells. Interleukin 1, a macrophage product that stimulates fibroblast migration, proliferation and synthetic activity, possesses the requisite properties to qualify for such a mediator.",
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