Interictal magnetoencephalographic findings related with surgical outcomes in lesional and nonlesional neocortical epilepsy

Rui Zhang, Ting Wu, Yingying Wang, Hongyi Liu, Yuanjie Zou, Wen Liu, Jing Xiang, Chaoyong Xiao, Lu Yang, Zhen Fu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: To investigate whether interictal magnetoencephalography (MEG) concordant with other techniques can predict surgical outcome in patients with lesional and nonlesional refractory neocortical epilepsy (NE). Methods: 23 Patients with lesional NE and 20 patients with nonlesional NE were studied. MEG was recorded for all patients with a 275 channel whole-head system. Synthetic aperture magnetometry (SAM) with excess kurtosis (g2) and conventional Equivalent Current Dipole (ECD) were used for MEG data analysis. 27 Patients underwent long-term extraoperative intracranial video electroencephalography (iVEEG) monitoring. Surgical outcomes were assessed based on more than 1-year of post-surgical follow-up using Engel classification system. Results: As we expected, both favorable outcomes (Engel class I or II) and seizure freedom outcomes (Engel class IA) were higher for the concordance condition (MEG findings are concordant with MRI or iVEEG findings) versus the discordance condition. Also the seizure free rate was significantly higher (χ 2 = 5.24, P < 0.05) for the patients with lesional NE than for the patients with nonlesional NE. In 30% of the patients with nonlesional NE, the MEG findings proved to be valuable for intracranial electrode implantation. Conclusions: This study demonstrates that a favorable post-surgical outcome can be obtained in most patients with concordant MEG and MRI results even without extraoperative iVEEG monitoring, which indicates that the concordance among different modalities could indicate a likelihood of better postsurgical outcomes. However, extraoperative iVEEG monitoring remains prerequisite to the patients with discordant MEG and MRI findings. For nonlesional cases, our results showed that MEG could provide critical information in the placement of intracranial electrodes.

Original languageEnglish (US)
Pages (from-to)692-700
Number of pages9
JournalSeizure
Volume20
Issue number9
DOIs
StatePublished - Nov 1 2011

Fingerprint

Magnetoencephalography
Epilepsy
Electrodes
Seizures
Magnetometry
Head
Electrocorticography

Keywords

  • Epilepsy surgery
  • Interictal magnetoencephalography
  • Lesional
  • Neocortical
  • Nonlesional

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Interictal magnetoencephalographic findings related with surgical outcomes in lesional and nonlesional neocortical epilepsy. / Zhang, Rui; Wu, Ting; Wang, Yingying; Liu, Hongyi; Zou, Yuanjie; Liu, Wen; Xiang, Jing; Xiao, Chaoyong; Yang, Lu; Fu, Zhen.

In: Seizure, Vol. 20, No. 9, 01.11.2011, p. 692-700.

Research output: Contribution to journalArticle

Zhang, Rui ; Wu, Ting ; Wang, Yingying ; Liu, Hongyi ; Zou, Yuanjie ; Liu, Wen ; Xiang, Jing ; Xiao, Chaoyong ; Yang, Lu ; Fu, Zhen. / Interictal magnetoencephalographic findings related with surgical outcomes in lesional and nonlesional neocortical epilepsy. In: Seizure. 2011 ; Vol. 20, No. 9. pp. 692-700.
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abstract = "Purpose: To investigate whether interictal magnetoencephalography (MEG) concordant with other techniques can predict surgical outcome in patients with lesional and nonlesional refractory neocortical epilepsy (NE). Methods: 23 Patients with lesional NE and 20 patients with nonlesional NE were studied. MEG was recorded for all patients with a 275 channel whole-head system. Synthetic aperture magnetometry (SAM) with excess kurtosis (g2) and conventional Equivalent Current Dipole (ECD) were used for MEG data analysis. 27 Patients underwent long-term extraoperative intracranial video electroencephalography (iVEEG) monitoring. Surgical outcomes were assessed based on more than 1-year of post-surgical follow-up using Engel classification system. Results: As we expected, both favorable outcomes (Engel class I or II) and seizure freedom outcomes (Engel class IA) were higher for the concordance condition (MEG findings are concordant with MRI or iVEEG findings) versus the discordance condition. Also the seizure free rate was significantly higher (χ 2 = 5.24, P < 0.05) for the patients with lesional NE than for the patients with nonlesional NE. In 30{\%} of the patients with nonlesional NE, the MEG findings proved to be valuable for intracranial electrode implantation. Conclusions: This study demonstrates that a favorable post-surgical outcome can be obtained in most patients with concordant MEG and MRI results even without extraoperative iVEEG monitoring, which indicates that the concordance among different modalities could indicate a likelihood of better postsurgical outcomes. However, extraoperative iVEEG monitoring remains prerequisite to the patients with discordant MEG and MRI findings. For nonlesional cases, our results showed that MEG could provide critical information in the placement of intracranial electrodes.",
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AU - Wu, Ting

AU - Wang, Yingying

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AU - Zou, Yuanjie

AU - Liu, Wen

AU - Xiang, Jing

AU - Xiao, Chaoyong

AU - Yang, Lu

AU - Fu, Zhen

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