Interferon β1a treatment modulates TH1 expression in γδ + T cells from relapsing-remitting multiple sclerosis patients

Cerise L. Elliott, Samia Y. Ei-Touny, Mary L. Filipi, Kathleen Healey, M. Patricia Leuschen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A paradigm exists that multiple sclerosis is causally related to dysregulation of TH1 inflammatory cytokines and TH2 antiinflammatory cytokines. The cytokine source(s) that initiate the imbalances are unknown. In this study, γδ, CD4, and CD8 T cell receptor-positive (TCR+) cells were isolated from the blood of 26 definitive relapsing-remitting multiple sclerosis patients prior to interferon β-1a (IFNβ1a) therapy and following 8-10 weeks of this therapy. The bioactivities of interferon γ (IFNγ), interleukin 10 (IL10), and interleukin 12 (IL12) were determined. The concentrations of IFNγ, IL10, and IL12 from each cell type did not change significantly with IFNβ1a treatment. The IL10 secreted by γδ TCR+ cells strongly correlated with the IL12 secreted by the same γδ TCR+ cells, supporting the paradigm. Furthermore, IFNβ1a therapy decreased the γδ TCR+ cell secretion of TH1 cytokines after 8-10 weeks of therapy.

Original languageEnglish (US)
Pages (from-to)200-209
Number of pages10
JournalJournal of Clinical Immunology
Volume21
Issue number3
DOIs
StatePublished - Jan 1 2001

Fingerprint

Relapsing-Remitting Multiple Sclerosis
Interferons
T-Lymphocytes
Interleukin-12
Interleukin-10
Cytokines
Therapeutics
T-Cell Antigen Receptor
Multiple Sclerosis
Anti-Inflammatory Agents

Keywords

  • Interferon β1a interleukin 12
  • Interleukin 10
  • Multiple sclerosis
  • γδ T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Interferon β1a treatment modulates TH1 expression in γδ + T cells from relapsing-remitting multiple sclerosis patients. / Elliott, Cerise L.; Ei-Touny, Samia Y.; Filipi, Mary L.; Healey, Kathleen; Leuschen, M. Patricia.

In: Journal of Clinical Immunology, Vol. 21, No. 3, 01.01.2001, p. 200-209.

Research output: Contribution to journalArticle

Elliott, Cerise L. ; Ei-Touny, Samia Y. ; Filipi, Mary L. ; Healey, Kathleen ; Leuschen, M. Patricia. / Interferon β1a treatment modulates TH1 expression in γδ + T cells from relapsing-remitting multiple sclerosis patients. In: Journal of Clinical Immunology. 2001 ; Vol. 21, No. 3. pp. 200-209.
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