Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior

L. S. Wakschlag, E. O. Kistner, D. S. Pine, G. Biesecker, K. E. Pickett, A. D. Skol, V. Dukic, R. J.R. Blair, B. L. Leventhal, N. J. Cox, J. L. Burns, K. E. Kasza, R. J. Wright, E. H. Cook

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Genetic susceptibility to antisocial behavior may increase fetal sensitivity to prenatal exposure to cigarette smoke. Testing putative gene × exposure mechanisms requires precise measurement of exposure and outcomes. We tested whether a functional polymorphism in the gene encoding the enzyme monoamine oxidase A (MAOA) interacts with exposure to predict pathways to adolescent antisocial behavior. We assessed both clinical and information-processing outcomes. One hundred seventy-six adolescents and their mothers participated in a follow-up of a pregnancy cohort with well-characterized exposure. A sex-specific pattern of gene × exposure interaction was detected. Exposed boys with the low-activity MAOA 5′ uVNTR (untranslated region variable number of tandem repeats) genotype were at increased risk for conduct disorder (CD) symptoms. In contrast, exposed girls with the high-activity MAOA uVNTR genotype were at increased risk for both CD symptoms and hostile attribution bias on a face-processing task. There was no evidence of a gene-environment correlation (rGE). Findings suggest that the MAOA uVNTR genotype, prenatal exposure to cigarettes and sex interact to predict antisocial behavior and related information-processing patterns. Future research to replicate and extend these findings should focus on elucidating how gene × exposure interactions may shape behavior through associated changes in brain function.

Original languageEnglish (US)
Pages (from-to)928-937
Number of pages10
JournalMolecular Psychiatry
Volume15
Issue number9
DOIs
StatePublished - Sep 1 2010

Fingerprint

Monoamine Oxidase
Tobacco Products
Minisatellite Repeats
Genotype
Untranslated Regions
Conduct Disorder
Genes
Automatic Data Processing
Adolescent Behavior
5' Untranslated Regions
Genetic Predisposition to Disease
Smoke
Mothers
Pregnancy
Brain
Enzymes

Keywords

  • MAOA
  • developmental psychopathology
  • gene + environment interaction
  • prenatal smoking

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Wakschlag, L. S., Kistner, E. O., Pine, D. S., Biesecker, G., Pickett, K. E., Skol, A. D., ... Cook, E. H. (2010). Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior. Molecular Psychiatry, 15(9), 928-937. https://doi.org/10.1038/mp.2009.22

Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior. / Wakschlag, L. S.; Kistner, E. O.; Pine, D. S.; Biesecker, G.; Pickett, K. E.; Skol, A. D.; Dukic, V.; Blair, R. J.R.; Leventhal, B. L.; Cox, N. J.; Burns, J. L.; Kasza, K. E.; Wright, R. J.; Cook, E. H.

In: Molecular Psychiatry, Vol. 15, No. 9, 01.09.2010, p. 928-937.

Research output: Contribution to journalArticle

Wakschlag, LS, Kistner, EO, Pine, DS, Biesecker, G, Pickett, KE, Skol, AD, Dukic, V, Blair, RJR, Leventhal, BL, Cox, NJ, Burns, JL, Kasza, KE, Wright, RJ & Cook, EH 2010, 'Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior', Molecular Psychiatry, vol. 15, no. 9, pp. 928-937. https://doi.org/10.1038/mp.2009.22
Wakschlag, L. S. ; Kistner, E. O. ; Pine, D. S. ; Biesecker, G. ; Pickett, K. E. ; Skol, A. D. ; Dukic, V. ; Blair, R. J.R. ; Leventhal, B. L. ; Cox, N. J. ; Burns, J. L. ; Kasza, K. E. ; Wright, R. J. ; Cook, E. H. / Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior. In: Molecular Psychiatry. 2010 ; Vol. 15, No. 9. pp. 928-937.
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